Advances in Targeting Signal Transduction Pathways
2012
Аутори:
McCubrey, James ASteelman, Linda S
Chappell, William H
Sun, Lin
Davis, Nicole M
Abrams, Stephen L
Franklin, Richard A
Cocco, Lucio
Evangelisti, Camilla
Chiarini, Francesca
Martelli, Alberto M
Libra, Massimo
Candido, Saverio
Ligresti, Giovanni
Malaponte, Graziella
Mazzarino, Maria C
Fagone, Paolo
Donia, Marco
Nicoletti, Ferdinando
Polesel, Jerry
Talamini, Renato
Baesecke, Joerg
Mijatović, Sanja
Maksimović-Ivanić, Danijela
Milella, Michele
Tafuri, Agostino
Dulinska-Litewka, Joanna
Laidler, Piotr
D'Assoro, Antonio B
Drobot, Lyudmyla
Umezawa, Kazuo
Montalto, Giuseppe
Cervello, Melchiorre
Demidenko, Zoya N
Тип документа:
Приказ (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Over the past few years, significant advances have occurred in both our understanding of the complexity of signal transduction pathways as well as the isolation of specific inhibitors which target key components in those pathways. Furthermore critical information is being accrued regarding how genetic mutations can affect the sensitivity of various types of patients to targeted therapy. Finally, genetic mechanisms responsible for the development of resistance after targeted therapy are being discovered which may allow the creation of alternative therapies to overcome resistance. This review will discuss some of the highlights over the past few years on the roles of key signaling pathways in various diseases, the targeting of signal transduction pathways and the genetic mechanisms governing sensitivity and resistance to targeted therapies.