Non-wild type antibiotic resistant Escherichia coli in the River Danube: a six-year-comparison
2021
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Аутори:
Koller, MichaelHack, Kerstin
Dielacher, Irina
Wachter, Julian
Schachner, Iris
Jakwerth, Stefan
Kolarević, Stoimir
Kračun-Kolarević, Margareta
Tóth, Erika
Savio, Domenico
Farnleitner, Andreas H.
Kittinger, Clemens
Kirschner, Alexander K.T.
Zarfel, Gernot
Остала ауторства
Sandu, CristinaCyffka, Bernd
Тип документа:
Конференцијски прилог (Објављена верзија)
,
© 2021 by the Aueninstitut Neuburg
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Introduction
The emerging occurrence of human induced antibiotic resistant bacteria (ARB) is not only limited to
clinical surroundings: they can also be found in the human population, animals and the water
environment. Large rivers are of great concern as regards the spreading of ARB. Thus, this ongoing
study ́s aim is to analyze the major propagation pathways and sources of ARB in the Danube, and to
do a six-year-comparison with data obtained in 2013.
Study design and methods
Within the frame of the 4th Joint Danube Survey (JDS) of the International Commission for the
Protection of the Danube River (ICPDR), water samples were taken at 36 sampling points along the
whole Danube. Escherichia coli as clinically relevant organisms were isolated and tested for their
susceptibility to 20 different antibiotics.
Results
1298 E. coli isolates have been tested so far. 11.33 % of them were multiresistant and 23.19 % were
resistant to one or two classes of antibiotics. The preliminary data show a very similar pattern
compared to the data obtained in 2013 (629 isolates) when 9.70 % of the isolates were multiresistant
and 29.09 % were resistant to one or two classes of antibiotics. Most of the resistances are still to
ampicillin and tetracycline. There are no resistances to carbapenems, colistin, amikacin and tigecycline.
But there is a significant increase in resistances to amoxicillin with clavulanic acid, moxifloxacin and
piperacillin with tazobactam and a significant decrease regarding tetracycline. 21 isolates are
confirmed ESBL-producers while in 2013 there were four.
Discussion
In comparison the data of 2013 and 2019 show a similar pattern regarding multiresistance. Regarding
resistances to single antibiotics significant changes could be determined. However, there are still many
of the isolates to be tested until the final analysis.
У:
- Sandu C, Cyffka B, editors. Proceedings: 43rd IAD Conference: Rivers and Floodplains in the Anthropocene: Upcoming Challenges in the Danube River Basin; 2021 Jun 9-11; Neuburg, Germany. 2021. p. 30.