Occurrence and spread of human- induced antimicrobial resistance in a large river water system: developing a holistic picture based on the Joint Danube Survey 4 activities
2021
Преузимање 🢃
Аутори:
Kirschner, Alexander K.T.Kittinger, Clemens
Schachner, Iris
Jakwerth, Stefan
Koller, Michael
Kolarević, Stoimir
Kračun-Kolarević, Margareta
Toumi, Marwene
Farkas, Rosza
Tóth, Erika
Kandler, W
Sulyok, M
Savio, Domenico
Farnleitner, Andreas H.
Zarfel, Gernot
Остала ауторства
Sandu, CristinaCyffka, Bernd
Тип документа:
Конференцијски прилог (Објављена верзија)
,
© 2021 by the Aueninstitut Neuburg
Метаподаци
Приказ свих података о документуАпстракт:
The problem of human-induced antimicrobial resistance (acquired due to human activities) is an
emerging concern in aquatic environments. The isolation of (facultative) pathogenic organisms with
acquired antibiotic resistance, even concerning last-line antibiotics, from rivers and lakes, is well
documented throughout the world. In the last few years, there has been a rapid increase in the number
of studies addressing these topics and their possible implications for human health. However, most
studies concentrate on a relatively limited methodology, e.g. applying non-quantitative and either
cultivation-based or direct-detection based molecular biological methods. In addition, often only small
geographic areas and short periods of time are covered. This is one of the reasons why many relevant
questions concerning the occurrence and spread of antimicrobial resistance in aquatic ecosystems still
remain unanswered.
The largest European river water survey (Joint Danube Survey 4) offered a unique opportunity to study
the occurrence and spread of human-induced antimicrobial resistance along the whole Danube River.
Within the research project, isolates from samples from the entire course of the Danube and their
main tributaries, including high frequency sampling at selected locations, have been collected and
analysed. Samples from the water compartment but also from submerged biofilms have been
considered. State-of-the-art quantitative molecular biological techniques and culture-based analyses
targeting different bacterial organisms have been combined with a large set of physical, chemical and
biological parameters to obtain a robust and comprehensive picture of the occurrence and spread of
human-induced antimicrobial resistance in the Danube River.
Based on the findings of this quantitative, integrative study approach, it seems likely to significantly
improve the current understanding on the importance on the spread and stabilization of human -
induced antibiotic resistance in large rivers. The results of this study will also be useful to guide future
monitoring and management strategies.
У:
- Sandu C, Cyffka B, editors. Proceedings: 43rd IAD Conference: Rivers and Floodplains in the Anthropocene: Upcoming Challenges in the Danube River Basin; 2021 Jun 9-11; Neuburg, Germany. 2021. p. 20.