A new step on the chemical profiles and pharmacological effects of three Scorzonera species ( S. hieraciifolia , S. hispanica and S. tomentosa )
2023
Аутори:
Ak, GunesZengin, Gokhan
Dall’Acqua, Stefano
Ferrarese, Irene
Sut, Stefania
Glamočlija, Jasmina
Soković, Marina
Nenadić, Marija
Chiavaroli, Annalisa
Recinella, Lucia
Leone, Sheila
Orlando, Giustino
Menghini, Luigi
Ferrante, Claudio
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2022 Informa UK Limited
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Приказ свих података о документуАпстракт:
The genus Scorzonera is one of the most important genera in the Asteraceae family, and members of the genus have great potential in traditional medicine systems. In this article we aimed to determine skin protective and antimicrobial effects of different extracts from the roots and aerial parts of three Scorzonera species (S. hieraciifolia, S. hispanica, S. tomentosa). Antimicrobial properties were evaluated against different pathogen bacterial and fungal strains, whereas protective effects were studied in isolated mouse skin specimens exposed to hydrogen peroxide. In this biological model, the levels of l-dopa and prostaglandin E2 (PGE2) were evaluated, as markers of tyrosinase activity and inflammation, respectively. All extracts were effective in blunting the increased hydrogen peroxide-induced l-dopa turnover and PGE2 level; thus, suggesting skin protection that could be partly related to the content of flavonoids, among which rutin, in the tested extracts. Additionally, all extracts were effective as antibacterial and antifungal agents; intriguing results were observed against Trichoderma viride, which was particularly sensitive to S. tomentosa root extracts. Therefore, the present study strengthens the importance of investigating herbal preparations obtained from plants belonging to the genus Scorzonera, for the management and prevention of inflammatory and infectious skin conditions.
Кључне речи:
Antimicrobial; Bioactive agents; Rutin; Scorzonera; Skin protectiveИзвор:
Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, 2023, 157, 1, 119-128Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- MIUR funds (FAR2021)
DOI: 10.1080/11263504.2022.2089766
ISSN: 1126-3504