Immune System as a Target of Xenobiotics Toxicity
Imunski sistem kao meta toksičnog delovanja ksenobiotika
2022
Authors:
Mirkov, IvanaPopov Aleksandrov, Aleksandra
Tucović, Dina
Kulaš, Jelena
Popović, Dušanka
Malešević, Anastasija
Kataranovski, Milena
Contributors
Pavlović, MiroslavPantović Pavlović, Marijana
Pavlović, Miomir
Document Type:
Conference object (Published version)
,
© 2022 by the Serbian Society of Corrosion and Materials Protection
Metadata
Show full item recordAbstract:
In addition to physical and chemical insults originating from nature (heavy metals, radiation, electromagnetic field), human beings are exposed to various agents as a result of progress in industry and technology (noise, pesticides, pharmaceuticals, personal care products, food additives, etc.) whose number continuously increases. Some of these agents may have adverse effects on the environment and human health and therefore every new product must be examined for its toxic potential and health risk. The immune system is an important homeostatic system that is included in response to various pathogens, but in other processes as well including wound healing and elimination of damaged cells and tumors. Due to its involvement in various physiological processes, alternation in immune system activity, as a consequence of exposure to xenobiotics, may cause an increase in the incidence of infections, tumors, allergies, and autoimmune diseases. Various tests that exist for the evaluation of immunotoxicity are grouped in two separate sets, tier one (experiments directed to measure the effect of xenobiotics on general immune parameters i.e. basic morphological and functional tests) and tier two(experiments aimed to more specifically define the cellular and biochemical mechanisms of toxicity). Evaluation of potential adverse effects of xenobiotics on the immune system is now incorporated into standard hazard identification and has improved human health risk assessment.
Keywords:
Immune system; Xenobiotics; Direct immunotoxicity; Risk assessment; Developmental immunotoxicityFunding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
In:
- Pavlović M, Pantović Pavlović M, Pavlović M, editors. Proceedings: Meeting point of the science and practice in the fields of corrosion, materials and environmental protection: XXIII YuCorr International Conference; 2022 May 16-19; Divčibare, Serbia. Belgrade: Serbian Society of Corrosion and Materials Protection; 2022. p. 7-13.