The effects of cadmium and coenzyme Q10 on antioxidant defence enzyme activities in the blood of rats
2000
Аутори:
Pavlović, SlađanOgnjanović, Branka
Štajn, Andraš Š.
Žikić, Radoslav V.
Saičić, Zorica
Petrović Vojislav M.
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2000 Polish Biophysical Society
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Приказ свих података о документуАпстракт:
The purpose of our study was to investigate the effects of cadmium (Cd) and coenzyme Qiu (criQu) on the activities of copper, zinc-containing superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in red blood cells (R111C) as well as giutathione-S-transferase (CST) in the plasma of male two months old Wistar alhino rats. The animals were divided hi live experimental groups as follows: (1) control (C), (2) Cr! (17 mg/day/kg body
mass + IOU Fel olive oil, every fifth day), (3) CoQio (16/mg/kg body mass, dissolved in olive oil, every fifth day), (4) Cd+C,o(bo (in the above mentioned amounts) and (5) olive oil (o. oil, 100 µl lin., every fifth day) and treated in the
course of 30 days. After the treatment, the animals were sacrificed and blood samples were prepared for the analysis. Our results show that Cd administered with olive oil did not exhibit toxic effects on CuZn SOD, CAT and CSH-Px ac-
tivities in RBC as well as GST activity in the plasma of rats. At the same time. Cotho by quenching the tree oxygen radicals and by inhibiting lipid peroxidation may improve the antioxidant defence enzyme activities in the blood of rats. Our investigations also show that olive oil exhibit some protective effects on Clan SOD, CAT and GSH-Px ac-
tivities in RUC and GST activity in the plasma of rats treated with Cd.
Кључне речи:
Cadmium; Coenzyme Q10; Antioxidant defence enzymes; Blood; ratsИзвор:
Current Topics in Biophysics, 2000, 24, 2, 159-165Финансирање / пројекти:
- The work reported here was supported by the Ministry of Science and Technology of Serbia, grant Nos 03E18 and 03E23.