Decreased Frequency of the Tumor Necrosis Factor α –308 Allele in Serbian Patients with Multiple Sclerosis
2003
Аутори:
Drulović, JelenaPopadić, Dušan
Mesaroš, Šarlota
Dujmović, Irena
Stojanović, Ivana D.
Miljković, Djordje
Stojsavljević, Nebojša
Pravica, Vera
Pekmezović, Tatjana
Bogdanović, Gradimir
Jarebinski, Mirjana
Mostarica Stojković, Marija
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2003, Silverchair Publisher
Метаподаци
Приказ свих података о документуАпстракт:
Tumor necrosis factor (TNF) alpha has been considered the prototypic cytopathogenic cytokine in multiple sclerosis (MS), but recently this cytokine has been shown to possess significant anti-inflammatory and neuroprotective effects in demyelinating diseases. It has been reported that the TNFalpha -308 polymorphism influences levels of TNFalpha production, and that the rare allele, TNF2, is associated with high TNFalpha production. We investigated the TNFalpha -308 polymorphism in 143 unrelated Serbian patients with MS and 123 ethnically matched, healthy individuals using the allele-specific restriction fragment length polymorphism polymerase chain reaction technique. The frequency of the TNF2 allele was significantly decreased in MS patients (14%) in comparison with controls (24%; p = 0.044). The TNF2 allele had no influence on disease behavior, since it was not associated with the course and severity of MS in this group of patients. The result suggests that in the Serbian population polymorphism at position -308 of TNFalpha or at an adjacent locus might have a role in MS susceptibility.
Кључне речи:
Multiple sclerosis; Tumor necrosis factor; Gene polymorphism; Familial multiple sclerosis; Allele-specific PCRИзвор:
European Neurology, 2003, 50, 1, 25-29
DOI: 10.1159/000070855
ISSN: 0014-3022
PubMed: 12824709