Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
2009
Аутори:
Bartholomaus, IngoKawakami, Naoto
Odoardi, Francesca
Schlager, Christian
Miljković, Đorđe
Ellwart, Joachim
Klinkert, Wolfgang
Flugel Koch, Cassandra
Issekutz, Thomas
Wekerle, Hartmut
Flugel, Alexander
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2009 by Macmillan Publishers Limited
Метаподаци
Приказ свих података о документуАпстракт:
The tissues of the central nervous system are effectively shielded from the blood circulation by specialized vessels that are impermeable not only to cells, but also to most macromolecules circulating in the blood. Despite this seemingly absolute seclusion, central nervous system tissues are subject to immune surveillance and are vulnerable to autoimmune attacks. Using intravital two-photon imaging in a Lewis rat model of experimental autoimmune encephalomyelitis, here we present in real-time the interactive processes between effector T cells and cerebral structures from their first arrival to manifest autoimmune disease. We observed that incoming effector T cells successively scanned three planes. The T cells got arrested to leptomeningeal vessels and immediately monitored the luminal surface, crawling preferentially against the blood flow. After diapedesis, the cells continued their scan on the abluminal vascular surface and the underlying leptomeningeal (pial) membrane. There, the T cells encountered phagocytes that effectively present antigens, foreign as well as myelin proteins. These contacts stimulated the effector T cells to produce pro-inflammatory mediators, and provided a trigger to tissue invasion and the formation of inflammatory infiltrations.
Извор:
Nature, 2009, 462, 7269, 94-98Финансирање / пројекти:
- Deutsche Forschungsgemeinschaft (SFB455 project A8 and SFB571 project C6) and the Hertie foundation (Hertie no.1.01.1/04/010)
DOI: 10.1038/nature08478
ISSN: 0028-0836
PubMed: 19829296