Influence of zirconium and copper sub-layer in cell integrations on femtosecond laser-processed Ti thin films
2023
Аутори:
Božinović, NevenaSavva, Kyriaki
Rajić, Vladimir
Popović, Maja
Tošić, Dragana
Janjetović, Kristina
Despotović, Ana
Zogović, Nevena
Stratakis, Emmanuel
Petrović, Suzana
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2023 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт:
The creation of novel biocompatible Ti-based thin films with a Zr or Cu sub-layer modified by ultrafast laser processing is studied. To prepare bioactive surfaces, ultrafast laser processing is focused on the formation of laser-induced periodic surface structures (LIPSS) with the production of oxide phases at the surfaces. Two differently designed multilayer thin films Ti/Cu/Ti and Ti/Zr/Ti were deposited on the silicon using the ion sputtering method. The Ti thin film contains Cu or Zr sub-layer (thickness of 10 nm) at the 10 nm below the surface. The composition and surface morphology variations for these systems, deposited and laser-processed under the same experimental conditions, were caused only by different thermo-physical properties of the sub-layer (Cu or Zr). The surface morphology in the form of LIPSS, led to improved cell adhesion and stable cells/thin films interface compared to as-deposited samples. Field-emission scanning electron microscopy and MTT analysis revealed that laser processing of both systems increased cell adhesion, proliferation, and metabolical activity of L929 mouse fibroblast cells compared to non-modified flat surfaces. Overall, the biocompatibility of Zr-containing thin films is better than Ti/Cu/Ti system. Further, laser processing and formation of LIPSS makes Ti/Zr/Ti thin films excellent candidate for biomedical.
Кључне речи:
Titanium thin films; Ultrafast laser processing; Laser-induced periodic surface structures (LIPSS); Bioactive surfacesИзвор:
Materials Chemistry and Physics, 2023, 308, 128286-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
- EU-H2020 research and innovation program grant N 101007417
- COST Action CA17126 -TUMIEE (supported by COST-European Cooperation in Science and Technology)
DOI: 10.1016/j.matchemphys.2023.128286
ISSN: 0254-0584