Role of claudins 3,4 and 7 in triple negative breast cancer progression
2023
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Аутори:
Jovanović, IrenaNedeljković, Milica
Medić-Milijić, Nataša
Spurnić, Igor
Milovanović, Zorka
Tomić, Tijana
Tanić, Nasta
Tanić, Nikola
Тип документа:
Конференцијски прилог (Објављена верзија)
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© 2023 by the Serbian Associaton for Cancer Research
Метаподаци
Приказ свих података о документуАпстракт:
Background: Breast cancer is the most commonly occurring malignancy and the leading cause of cancer-related death in women. Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and is associated with high recurrence rates, high incidence of distant metastases and poor overall survival. The aim of this study was to investigate the role of cludin 3, claudin 4 and claudin 7 in TNBC promotion and progression. Claudins are tight junction (TJ) integral membrane proteins that are key regulators of the paracellular pathway. Materials and methods: This is a retrospective analysis of 125 patients with triple-negative breast cancer operated at the Institute of Oncology and Radiology of Serbia in the period from 2009 to 2014. The expression of claudin 3, 4 and 7 was observed using the immunohistochemical staining method. The Allred scoring system was used with cut-off values: ≤4 and >4 (low/high expression). Results: Our results showed that the expression of claudins 3 and 4 correlate with higher nuclear gradus and low desease free interval (DFI). More over, the expression of claudin 3 and claudin 4 correlates (Spearman test p˂0.0001). In addition, high expression of claudin 7 is signifi cantly related to low DFI of patients (p˂0.005) and distant metastases. Conclusions: We concluded that claudin 3, claudin 4 and claudin 7 have significant impact on TNBC progression. Namely, elevated expression of these proteins significantly correlates with low DFI and distant metastases. In other words, elevated expression of claudins is a bad news for TNBC patients. Therefore, the expression of claudins could be a good prognostic marker for TNBC patients and potential target for future therapy protocols.
Кључне речи:
Triple-negative breast cancer (TNBC); claudin 3; claudin 4; claudin 7Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
У:
- Proceedings book of The Sixth Congress of The Serbian Association for Cancer Research with international participation: From Collaboration to Innovation in Cancer Research; 2023 Oct 2-4; Belgrade, Serbia. Belgrade, Serbia: Serbian Associaton for Cancer Research; 2023. p. 63. (Oncology Insights; No. 1).