Essential Trace Element Levels in Multiple Sclerosis: Bridging Demographic and Clinical Gaps, Assessing the Need for Supplementation
2024
Аутори:
Stojsavljević, AleksandarJagodić, Jovana
Pavlović, Slađan
Dinčić, Evica
Kuveljić, Jovana
Manojlović, Dragan
Živković, Maja
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2024 Elsevier GmbH
Метаподаци
Приказ свих података о документуАпстракт:
Background: Multiple sclerosis (MS) is a chronic demyelinating disorder intricately linked to perturbations in
trace element levels. While previous studies have explored circulating trace elements in a limited sample, understanding the impact of demographic and clinical variables on the elemental profile within a larger cohort
remains elusive.
Methods: This study aimed to evaluate essential trace elements (Cr, Mn, Co, Cu, Zn, and Se) in the sera of 215 MS
patients compared to a meticulously matched control group of 100 individuals with similar gender and age. Our
main objective was to identify potential variations in elemental profiles based on demographic and clinical
parameters among MS patients, elucidating the prospective relevance of supplementing specific essential trace
elements.
Results: Data indicated a significant decrease in serum levels of Mn, Co, Zn, and Se, and an increase in Cr in MS
patients compared to controls. These trace elements not only discriminated between MS patients and controls but
also exhibited distinctive capabilities among demographic subgroups. Gender, smoking habits, and age strata
(20–40 years and 41–60 years) revealed discernible variations in elemental profiles between MS patients and
their control counterparts. Se demonstrated the singular ability to stratify cases of extreme MS severity, mild
relapsing-remitting MS (RRMS) and highly severe secondary progressive MS (SPMS). In contrast, Co significantly
differentiated RRMS from primary progressive MS (PPMS), while Cu significantly differentiated SPMS from
PPMS. Additionally, Cu showed a negative correlation with MSSS, while Mn and Zn showed a positive correlation
with EDSS.
Conclusion: These findings underscore a substantive deficiency in Mn, Co, Zn, and Se in the MS cohort, supporting
targeted supplementation with these trace elements. This study provides a comprehensive understanding of the
intricate relationship between essential trace elements and MS, paving the way for further research into
personalized nutritional interventions for this complex neurological disorder.
Кључне речи:
Trace elements; Multiple sclerosis; Essentiality; Demographic/clinical parameters; Deficiency; SupplementationИзвор:
Journal of Trace Elements in Medicine and Biology, 2024, 83, 127421-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)