Cytotoxic activity of sesquiterpene lactones from Inula britannica on human cancer cell lines
2013
Authors:
Fischedick, Justin TPešić, Milica
Podolski-Renić, Ana
Banković, Jasna Z.
de Vos, Ric CH
Perić, Marija
Todorović, Slađana
Tanić, Nikola T
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Five new sesquiterpene lactones (1-5) were isolated from Inula britannica collected in the wild from Serbia along with five known compounds (6-10). Sesquiterpene lactones were isolated using centrifugal partition chromatography followed by combination of flash chromatography and semi-preparative HPLC. Isolated compounds were screened for cytotoxic activity on four different human cancer cell lines and their multi-drug resistant counterparts, as well as on normal human keratinocytes. Sesquiterpene lactones showed similar cytotoxic activity toward drug sensitive and drug resistant cancer cell lines. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.