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Advances in Targeting Signal Transduction Pathways
dc.creator | McCubrey, James A | |
dc.creator | Steelman, Linda S | |
dc.creator | Chappell, William H | |
dc.creator | Sun, Lin | |
dc.creator | Davis, Nicole M | |
dc.creator | Abrams, Stephen L | |
dc.creator | Franklin, Richard A | |
dc.creator | Cocco, Lucio | |
dc.creator | Evangelisti, Camilla | |
dc.creator | Chiarini, Francesca | |
dc.creator | Martelli, Alberto M | |
dc.creator | Libra, Massimo | |
dc.creator | Candido, Saverio | |
dc.creator | Ligresti, Giovanni | |
dc.creator | Malaponte, Graziella | |
dc.creator | Mazzarino, Maria C | |
dc.creator | Fagone, Paolo | |
dc.creator | Donia, Marco | |
dc.creator | Nicoletti, Ferdinando | |
dc.creator | Polesel, Jerry | |
dc.creator | Talamini, Renato | |
dc.creator | Baesecke, Joerg | |
dc.creator | Mijatović, Sanja | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Milella, Michele | |
dc.creator | Tafuri, Agostino | |
dc.creator | Dulinska-Litewka, Joanna | |
dc.creator | Laidler, Piotr | |
dc.creator | D'Assoro, Antonio B | |
dc.creator | Drobot, Lyudmyla | |
dc.creator | Umezawa, Kazuo | |
dc.creator | Montalto, Giuseppe | |
dc.creator | Cervello, Melchiorre | |
dc.creator | Demidenko, Zoya N | |
dc.date.accessioned | 2017-11-23T11:12:07Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2012 | sr |
dc.identifier.issn | 1949-2553 | sr |
dc.identifier.other | Rad_konverzija_3066 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1071 | |
dc.description.abstract | Over the past few years, significant advances have occurred in both our understanding of the complexity of signal transduction pathways as well as the isolation of specific inhibitors which target key components in those pathways. Furthermore critical information is being accrued regarding how genetic mutations can affect the sensitivity of various types of patients to targeted therapy. Finally, genetic mechanisms responsible for the development of resistance after targeted therapy are being discovered which may allow the creation of alternative therapies to overcome resistance. This review will discuss some of the highlights over the past few years on the roles of key signaling pathways in various diseases, the targeting of signal transduction pathways and the genetic mechanisms governing sensitivity and resistance to targeted therapies. | en |
dc.description.sponsorship | USAMRMC [BC022276]; Intramural RECDA Award; Italian Association for Cancer Research (AIRC); Italian Ministero dellIstruzione, dellUniversita e della Ricerca (Ministry forEducation, Universities and Research) - MIUR PRIN; FIRB-MERIT [RBNE08YYBM]; Itali | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Oncotarget | sr |
dc.title | Advances in Targeting Signal Transduction Pathways | en |
dc.type | review | |
dc.rights.license | ARR | |
dcterms.abstract | Маззарино, Мариа Ц; Цхаппелл, Wиллиам Х; Сун, Лин; Давис, Ницоле М; Aбрамс, Степхен Л; Франклин, Рицхард A; Стеелман, Линда С; МцЦубреy, Јамес A; Цоццо, Луцио; Евангелисти, Цамилла; Цхиарини, Францесца; Мартелли, Aлберто М; Либра, Массимо; Цандидо, Саверио; Лигрести, Гиованни; Малапонте, Гразиелла; Фагоне, Паоло; Дониа, Марцо; Ницолетти, Фердинандо; Полесел, Јеррy; Таламини, Ренато; Баесецке, Јоерг; Милелла, Мицхеле; Тафури, Aгостино; Дулинска-Литеwка, Јоанна; Лаидлер, Пиотр; Д'Aссоро, Aнтонио Б; Дробот, Лyудмyла; Умезаwа, Казуо; Монталто, Гиусеппе; Цервелло, Мелцхиорре; Демиденко, Зоyа Н; Мијатовић, Сања A.; Максимовић-Иванић, Данијела Д.; | |
dc.citation.issue | 12 | sr |
dc.citation.volume | 3 | sr |
dc.citation.spage | 69 | sr |
dc.citation.epage | 1521 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1071 |
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