dc.creator | Vuletić, Ana | |
dc.creator | Konjević, Gordana | |
dc.creator | Milanović, Desanka | |
dc.creator | Ruždijić, Sabera | |
dc.creator | Jurisić, Vladimir | |
dc.date.accessioned | 2017-11-23T11:08:34Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2010 | sr |
dc.identifier.issn | 1219-4956 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1350 | |
dc.description.abstract | Retinoic acid (RA), similar to specific growth factors, can induce differentiation of proliferating promyelocytic precursors into terminally differentiated granulocytes, although little is known about effects of its 13-cis isomer on promyelocytic leukemia (PML). In this study we demonstrate that 13-cis-RA has a dose and time-dependant antiproliferative effect on HL-60 PML cell line, that it induces cell accumulation in resting G0/G1 phase of the cell cycle followed by an increase in CD11b granulocyte differentiation antigen expression. The obtained increase in the percentage of HL-60 cells in G0/G1 phase and complementary decrease in S phase of the cell cycle are accompanied by a decrease in the expression of cell cycle regulatory molecule cyclin B1. We also show the induction of interferon regulatory factor-I (IRF- I) transcription that can, also, to some extent contribute to the antiproliferative effect of l 3-cis-RA. Furthermore, down-regulation of BcI-2 protein expression in I 3-cis-RA treated HL-60 cells may contribute to sensitivity to apoptosis of growth arrested HL-60 promyelocytic cells. | en |
dc.description.sponsorship | Ministry of Science and technology of the Republic of Serbia [145056] | sr |
dc.language.iso | English | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145056/RS// | |
dc.rights | restrictedAccess | |
dc.source | Pathology & Oncology Research | sr |
dc.title | Antiproliferative Effect of 13-cis-Retinoic Acid is Associated with Granulocyte Differentiation and Decrease in Cyclin B1 and Bcl-2 Protein Levels in G0/G1 Arrested HL-60 Cells | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Коњевић, Гордана; Вулета, Aна; Јурисић, Владимир; Милановић, Десанка Ј.; Руждијић, Сабера; | |
dc.rights.holder | © Arányi Lajos Foundation 2010 | |
dc.citation.issue | 3 | sr |
dc.citation.volume | 16 | sr |
dc.identifier.doi | 10.1007/s12253-009-9241-2 | |
dc.identifier.scopus | 2-s2.0-77956886917 | |
dc.identifier.wos | 000282230600013 | |
dc.citation.spage | 393 | |
dc.citation.epage | 401 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |