dc.creator | Saroglou, Vasiliki | |
dc.creator | Zervou, Maria | |
dc.creator | Karioti, Anastasia | |
dc.creator | Rančić, Ana | |
dc.creator | Dimas, Kostas | |
dc.creator | Koukoulitsa, Catherine | |
dc.creator | Skaltsa, Helen D | |
dc.date.accessioned | 2017-11-23T11:10:50Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2010 | sr |
dc.identifier.issn | 0163-3864 | sr |
dc.identifier.other | Rad_konverzija_3398 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1403 | |
dc.description.abstract | Nine sesquiterpene lactones, anthemin A (1), 1 alpha-hydroxydeacetylirinol-4 alpha,5 beta-epoxide (2), anthemin C (3), tatridin A (4), 1-epi-tatridin B (5), anthemin B (6), 6-deacetyl-beta-cyclopyrethrosin (7), elegalactone A (8), and 1 beta,4 alpha,6 alpha-trihydroxyeudesm-11-en-8 alpha-12-olide (9), were isolated front the aerial parts of A. melanolepis in addition to eight known flavonoids and three phenolic acids. Compounds 1, 3, and 6 are new natural products. The structures of the compounds were deduced by spectroscopic methods. The in vitro antimicrobial potential of the isolated sesquiterpene lactones four Gram-positive and five Gram-negative bacteria and One fungus was evaluated using the against microdilution method, and their in vitro cytotoxic activity was determined against a panel of human tumor cell lines. Furthermore. The pharmacokinetic profile Of the sesquiterpene lactones was investigated using computational methods. | en |
dc.description.sponsorship | ESF (European Social Fund); National Resources [70/3/7171] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Journal of Natural Products | sr |
dc.title | Sesquiterpene Lactones from Anthemis melanolepis and Their Antibacterial and Cytotoxic Activities. Prediction of Their Pharmacokinetic Profile | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Димас, Костас; Зервоу, Мариа; Коукоулитса, Цатхерине; Ранчић, Aна; Скалтса, Хелен Д; Сароглоу, Василики; Кариоти, Aнастасиа; | |
dc.citation.issue | 2 | sr |
dc.citation.volume | 73 | sr |
dc.citation.epage | 246 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1403 | |