Приказ основних података о документу
The thyroid C cells of ovariectomized rats treated with estradiol
dc.creator | Filipović, Branko | |
dc.creator | Šošić-Jurjević, Branka | |
dc.creator | Nestorović, Nataša | |
dc.creator | Manojlović-Stojanoski, Milica | |
dc.creator | Kostić, Nada D | |
dc.creator | Milošević, Verica | |
dc.creator | Sekulić, Milka I. | |
dc.date.accessioned | 2017-11-23T11:15:41Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2003 | sr |
dc.identifier.issn | 0948-6143 | sr |
dc.identifier.other | Rad_konverzija_3756 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1761 | |
dc.description.abstract | The structure and function of thyroid C cells were studied in ovariectomized (Ovx) adult female rats without and after chronic treatment with estradiol dipropionate (EDP). A peroxidase-antiperoxidase method was applied for localization of calcitonin (CT) in the C cells. Morphometric changes in their volume, nuclei, and relative volume density were evaluated in comparison with sham-operated control rats using a stereological method. The number of C cells was calculated. CT content in the sera was determined by radioimmunoassay. Ovariectomy (Ovx) led to a 21% increase in body weight (P<0.005), while treatment of Ovx rats with EDP decreased body weight by 25% (P<0.01). The immunoreactivity for CT in C cells of the Ovx rats was markedly increased. Significant decreases in the volume of C cells (by 13%; P<0.05) and serum CT (by 45%) were recorded, while the C cell number increased by 59% (P<0.05) in relation to the corresponding controls. The treatment of Ovx rats with EDP caused conspicuous degranulation of the C cells. The cellular volume was increased by 11% and serum CT by 36% in comparison with Ovx animals. At the same time a decrease in C cell number by 29% (P<0.05) was evident. It may be concluded that estradiol deficiency after Ovx reduced the synthesis and release of CT, while chronic treatment of these animals with EDP had a positive effect on the secretory activity of thyroid C cells. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.publisher | Springer-Verlag | |
dc.rights | restrictedAccess | |
dc.source | Histochemistry and Cell Biology | sr |
dc.title | The thyroid C cells of ovariectomized rats treated with estradiol | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Костић, Нада Д; Милошевић, Верица Љ.; Секулић, Милка И.; Манојловић-Стојаноски, Милица; Несторовић, Наташа М.; Шошић-Јурјевић, Бранка Т.; Филиповић, Бранко; | |
dc.rights.holder | © 2003, Springer-Verlag | |
dc.citation.issue | 5 | sr |
dc.citation.volume | 120 | sr |
dc.identifier.doi | 10.1007/s00418-003-0578-4 | |
dc.identifier.pmid | 14564528 | |
dc.identifier.scopus | 2-s2.0-0347477352 | |
dc.identifier.wos | 000186824800008 | |
dc.citation.spage | 409 | |
dc.citation.epage | 414 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1761 |