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A controlled trial of combination of methionine and antioxidants in ALS patients
dc.creator | Stević, Zorica D | |
dc.creator | Nikolić, Aleksandra L. | |
dc.creator | Blagojević, Duško | |
dc.creator | Saičić, Zorica | |
dc.creator | Kocev, Nikola I | |
dc.creator | Apostolski, Slobodan A | |
dc.creator | Spasić, Mihajlo | |
dc.date.accessioned | 2017-11-23T11:15:41Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2001 | sr |
dc.identifier.issn | 0354-3447 | sr |
dc.identifier.other | Rad_konverzija_3806 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1811 | |
dc.description.abstract | We assessed a combination of methionine, vitamin E and selenium, as Alsemet(R) in a double blind, placebo controlled trial in 28 out patients with amyotrophic lateral sclerosis. After 12 months, 50% of patients in the placebo group were still alive as compared to 81.3% in the Alsemet(R) group (p<0.05). The rate of deterioration, limb and bulbar-function scores (p<0.05) and muscle-testing score (p<0.025) were significantly lower in the Alsemet(R) group than in the placebo group at the end of a sixth month treatment. We noted a significant increase in GSH-Px activity (p<0.05), as well as an increase in the amount of Vit E (p<0.05) in the Alsemet(R) group in comparison to the placebo group during the clinical trial. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Jugoslovenska Medicinska Biohemija-Yugoslav Medical Biochemistry | sr |
dc.title | A controlled trial of combination of methionine and antioxidants in ALS patients | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Саичић, Зорица; Стевић, Зорица Д; Николић, Aлександра Л.; Коцев, Никола И; Aпостолски, Слободан A; Спасић, Михајло Б.; Благојевић, Душко П.; | |
dc.citation.issue | 4 | sr |
dc.citation.volume | 20 | sr |
dc.citation.epage | 228 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1811 |
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