Tumor necrosis factor stimulates expression of CXCL12 in astrocytes
2015
Authors:
Blaževski, JanaPetković, Filip
Momčilović, Miljana
Jevtić, Bojan
Stojkovic, Marija Mostarica
Miljković, Đorđe
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
It has been increasingly appreciated that tumor necrosis factor (TNF)
performs various protective and anti-inflammatory functions in multiple
sclerosis (MS) and its animal model experimental autoimmune
encephalomyelitis (EAE). Recently, CXCL12 has been identified as a key
inhibitor of leukocyte entry into the central nervous system (CNS) and
as a regulator of inflammation resulting from the invasion. Here, a
positive correlation between expression of TNF and CXCL12 in the CNS
samples of EAE rats is presented. Also, it is shown that TNF potentiates
CXCL12 expression in astrocytes. These results contribute to a view that
TNF produced within the CNS plays a protective role in
neuroinflammation. (C) 2015 Elsevier GmbH. All rights reserved.
Keywords:
Experimental autoimmune encephalomyelitis; Tumor necrosis factor; Astrocyte; NeuroinflammationSource:
Immunobiology, 2015, 220, 7, 845-850
DOI: 10.1016/j.imbio.2015.01.007
ISSN: 0171-2985