Aging induced cortical drive alterations during sleep in rats
Abstract:
We followed the impact of healthy aging on cortical drive during sleep
in rats by using the corticomuscular coherence (CMC).
We employed the chronic electrodes implantation for sleep recording in
adult, male Wistar rats, and followed the aging impact during sleep from
3 to 5.5 months age. We have analyzed the sleep/wake states
architecture, and the sleep/wake state related EEG microstructure and
CMCs.
We evidenced the topographically distinct impact of aging on sleep/wake
states architecture within the sensorimotor (SMCx) vs. motor cortex
(MCx) from 4.5 to 5.5 months age. Healthy aging consistently altered
only the SMCx sleep/wake states architecture, and increased the delta
and beta CMCs through both cortical drives during Wake, but only through
the MCx drive during REM. According to the delta and beta CMCs values,
aging impact through the SMCx drive was opposite, but it was convergent
through the MCx drive during Wake vs. REM, and there was a dual and
inverse mode for the motor control during REM. (C) 2015 Elsevier Ireland
Ltd. All rights reserved.
Keywords:
Corticomuscular coherence; Aging; Sleep; Cortical driveSource:
Mechanisms of Ageing and Development, 2015, 146, 12-22
DOI: 10.1016/j.mad.2015.03.002
ISSN: 0047-6374