New insights into male (in)fertility: the importance of NO
2015
Autori:
Buzadžić, Biljana J.Vucetic, M.
Janković, Aleksandra
Stancic, A.
Korac, A.
Korać, Bato
Otašević, Vesna
Tip dokumenta:
Prikaz (Objavljena verzija)
,
© 2014 The British Pharmacological Society
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Infertility is a global problem that is on the rise, especially during
the last decade. Currently, infertility affects approximately 10-15\% of
the population worldwide. The frequency and origin of different forms of
infertility varies. It has been shown that reactive oxygen and nitrogen
species (ROS and RNS) are involved in the aetiology of infertility,
especially male infertility. Various strategies have been designed to
remove or decrease the production of ROS and RNS in spermatozoa, in
particular during in vitro fertilization. However, in recent years it
has been shown that spermatozoa naturally produce a variety of ROS/RNS,
including superoxide anion radical (O-2(-)), hydrogen peroxide and NO.
These reactive species, in particular NO, are essential in regulating
sperm capacitation and the acrosome reaction, two processes that need to
be acquired by sperm in order to achieve fertilization potential. In
addition, it has recently been shown that mitochondrial function is
positively correlated with human sperm fertilization potential and
quality and that NO and NO precursors increase sperm motility by
increasing energy production in mitochondria. We will review the new
link between sperm NO-driven redox regulation and infertility herein. A
special emphasis will be placed on the potential implementation of new
redox-active substances that modulate the content of NO in spermatozoa
to increase fertility and promote conception.
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Ključne reči:
nitric oxide; infertility; spermatozoa; in vitro fertilization; mitochondria; redox regulation; capacitation; Acrosome reaction; motilityIzvor:
British Journal of Pharmacology, 2015, 172, 6, SI, 1455-1467
DOI: 10.1111/bph.12675
ISSN: 1476-5381