dc.creator | Popovic, Visnja | |
dc.creator | Stojković, Dejan | |
dc.creator | Nikolić, Miloš | |
dc.creator | Heyerick, Arne | |
dc.creator | Petrovic, Silvana | |
dc.creator | Soković, Marina | |
dc.creator | Niketic, Marjan | |
dc.date.accessioned | 2016-05-23T11:00:06Z | |
dc.date.available | 2016-05-23T11:00:06Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 2042-650X | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2068 | |
dc.description.abstract | Antimicrobial properties of extracts of underground parts of three
Laserpitium L. (Apiaceae) species, namely Laserpitium latifolium L.,
Laserpitium zernyi Hayek and Laserpitium ochridanum Micevski, were
investigated. The investigated species are widely used as functional
foods, as spices and for preparations in traditional medicine for
treating complaints connected with infection and inflammation.
Furthermore, antimicrobial and antibiofilm effects of laserpitine, the
most abundant compound in the chloroform extract of Laserpitium
latifolium, and guaianolide sesquiterpene lactones, such as,
isomontanolide, montanolide and tarolide, principal components of the
extracts of Laserpitium zernyi and Laserpitium ochridanum were assessed.
The antimicrobial activity was tested using the microdilution method
against five pathogenic bacteria and five fungi, as well as in the
microplate biofilm assay on two Candida clinical isolates (C. albicans
and C. krusei). Among the extracts, Laserpitium latifolium showed the
most prominent activity. Isolated metabolites exerted higher effects
against fungal than against bacterial strains, isomontanolide being the
most active. Interestingly, all constituents showed higher potential on
inhibition of biofilm formation than fluconazole, a reference compound.
Tested metabolites may be good novel agents with high antifungal and
antibacterial potential that might find practical applications in food
industry as food preservatives in order to retard the growth of food
spoiling microbes, but only after detailed safety assessments. | en |
dc.description.sponsorship | Erasmus Mundus Action 2 program of European Comission {[}1011092];
Ministry of Education, Science and Technological Development of Republic
of Serbia {[}173032, 173021] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Food & Function | |
dc.title | Extracts of three Laserpitium L. species and their principal components
laserpitine and sesquiterpene lactones inhibit microbial growth and
biofilm formation by oral Candida isolates | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Петровиц, Силвана; Поповиц, Висња; Стојковиц, Дејан; Николиц, Милос; Хеyерицк, Aрне; Никетиц, Марјан; Соковић, Марина; | |
dc.citation.issue | 4 | |
dc.citation.volume | 6 | |
dc.identifier.doi | 10.1039/c5fo00066a | |
dc.identifier.scopus | 2-s2.0-84927596189 | |
dc.identifier.wos | 000354522900016 | |
dc.citation.spage | 1205 | |
dc.citation.epage | 1211 | |
dc.type.version | publishedVersion | en |