Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester ligands
2015
Authors:
Eichhorn, ThomasHey-Hawkins, Evamarie
Maksimović-Ivanić, Danijela
Mojić, Marija
Schmidt, Juergen
Mijatović, Sanja
Schmidt, Harry
Kaluđerović, Goran N.
Document Type:
Article (Published version)
,
© 2014 John Wiley & Sons, Ltd.
Metadata
Show full item recordAbstract:
Neutral binuclear ruthenium complexes 1, 2, 3, 4, 5, 6, 7, 8 of the
general formula {[}\{RuCl2((6)-p-cym)\}(2)-(NN)] (NN=bis(nicotinate)-
and bis(isonicotinate)-polyethylene glycol esters:
(3-py)COO(CH2CH2O)(n)CO(3-py) and (4-py)COO(CH2CH2O)(n)CO(4-py), n
=1-4), as well as mononuclear
{[}RuCl2((6)-p-cym)((3-py)COO(CH2CH2OCH3)-N)], complex 9, were
synthesized and characterized using elemental analysis and electrospray
ionization high-resolution mass spectrometry, infrared, H-1 NMR and C-13
NMR spectroscopies. Stability of the binuclear complexes in the presence
of dimethylsulfoxide was studied. Furthermore, formation of a cationic
complex containing bridging pyridine-based bidentate ligand was
monitored using H-1 NMR spectroscopy. Ligand precursors, polyethylene
glycol esters of nicotinic (L12HCl-L42HCl and L9HCl) and isonicotinic
acid dihydrochlorides (L52HCl-L82HCl), binuclear ruthenium(II) complexes
1, 2, 3, 4, 5, 6, 7, 8 and mononuclear complex 9 were tested for in
vitro cytotoxicity against 518A2 (melanoma), 8505C (anaplastic thyroid
cancer), A253 (head and neck tumour), MCF-7 (breast tumour) and SW480
(colon carcinoma) cell lines. Copyright (c) 2014 John Wiley \& Sons,
Ltd.
Keywords:
Ruthenium(II) complexes; Nicotinic acid; Isonicotinic acid; Polyethylene glycol esters; CytotoxicitySource:
Applied Organometallic Chemistry, 2015, 29, 1, 20-25Funding / projects:
- Molecular mechanisms of physiological and pharmacological control of inflammation and cancer (RS-MESTD-Basic Research (BR or ON)-173013)
- European Union and the Free State of Saxony. Grant Number: 100099597
DOI: 10.1002/aoc.3238
ISSN: 1099-0739