Chemical composition, antimicrobial, and cytotoxic properties of five Lamiaceae essential oils
2014
Аутори:
Nikolić, MilošJovanovic, Katarina K.
Markovic, Tatjana
Markovic, Dejan
Gligorijevic, Nevenka
Radulovic, Sinia
Soković, Marina
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The aim of this study was to assess the biological activity of essential
oils from five Lamiaceae species, Mentha piperita, Mentha pulegium,
Lavandula angustifolia, Satureja montana and Salvia lavandulifolia, for
their chemical composition, antimicrobial and cytotoxic properties. Gas
chromatography coupled with FID and MS of essential oils revealed
menthol (47.5\%), pulegone (68.7), linalool (40.3\%), thymol (44.6\%),
and camphor (29.1\%) to be major oils' components, respectively. Minimum
inhibitory (MIC) and minimum bactericidal/fungicidal (MBC/MFC)
concentrations were determined by microdilution method. Seven bacterial
species, representing clinical specimens, including Streptococcus
mutans, Streptococcus sanguis, Streptococcus salivarius, Streptococcus
pyogenes, Pseudomonas aeruginosa, Lactobacillus acidophilus, and
Enterecoccus feacalis, and fifty eight clinical oral Candida spp.
isolates along with three reference strains were used in experiment. All
essential oils (EOs) exhibited a significant antimicrobial activity
against all tested microorganisms; the oil of S. montana proved to be
the most potent one (MIC 30.0-630.0 mu g/mL, MBC 60.0-250.0 mu g/mL; MIC
0.9-1.0 mu g/mL; MFC 1.0-3.0 mu g/mL). In addition, the oil also
revealed the highest cytotoxic activity against tested cell lines,
presenting IC50 values from 40.13 to 65.51 mu g/mL, with mild
selectivity towards HeLa cells observed in regard to the normal cell
line (MRC-5). In addition to the herbs traditional use in food and
pharmacy, results of this study proved the great potential of their
essential oils for application in oral disease and anticancer
treatments. (C) 2014 Elsevier B.V. All rights reserved.
Кључне речи:
Lamiaceae; Essential oils; Antimicrobial; Cytotoxic activityИзвор:
Industrial Crops and Products, 2014, 61, 225-232
DOI: 10.1016/j.indcrop.2014.07.011
ISSN: 1872-633X