Anticancer Potential of (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing kappa P and kappa P,kappa S-Coordinated Ph2PCH2CH2CH2S(O)(x)Ph (x=0-2) Ligands
2014
Аутори:
Ludwig, GerdRandelovic, Ivan
Maksimović-Ivanić, Danijela
Mijatović, Sanja
Bulatović, Mirna Z.
Miljković, Đorđe
Korb, Marcus
Lang, Heinrich
Steinborn, Dirk
Kaluđerović, Goran N.
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Iridium(III) complexes of the type
{[}Ir(eta(5)-C5Me5)Cl-2\{Ph2PCH2-CH2CH2S(O)(x)Ph-kappa P\}] (x=0-2; 1-3)
and {[}Ir(eta(5)-C5Me5)Cl\{Ph2PCH2-CH2CH2S(O)(x)Ph-kappa P,kappa
S\}]{[}PF6] (x=0-1; 4 and 5) with 3-(diphenyl-phosphino)propyl phenyl
sulfide, sulfoxide, and sulfone ligands Ph2PCH2CH2CH2S(O)(x)Ph were
designed, synthesized, and characterized fully, including X-ray
diffraction analyses for complexes 3 and 4. In vitro studies against
human thyroid carcinoma (8505C), submandibular carcinoma (A253), breast
adenocarcinoma (MCF-7), colon adenocarcinoma (SW480), and melano-ma
(518A2) cell lines provided evidence for the high biological potential
of the neutral and cationic iridium(III) complexes. Neutral iridium(III)
complex 5 proved to be the most active, with IC50 values up to about 0.1
mu m, representing activities of up to one order of magnitude higher
than cisplatin. Using 8505C cells, apoptosis was shown to be the main
mechanism through which complex 5 exerts its tumoricidal action. The
described iridium(III) complexes represent potential leads in the search
for novel metal-based anticancer agents.
Кључне речи:
apoptosis; cytotoxic agents; iridium(III) complexes; metal-based drugs; sulfur-functionalized phosphorus ligandsИзвор:
Chemmedchem, 2014, 9, 7, 1586-1593
DOI: 10.1002/cmdc.201300479
ISSN: 1860-7187