Further in vitro evaluation of antiradical and antimicrobial activities of phytol
2014
Authors:
Pejin, B.Savic, A.
Soković, Marina
Glamočlija, Jasmina
Ćirić, Ana
Nikolic, M.
Radotic, K.
Mojovic, M.
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
The antiradical activity of phytol was evaluated by electron
paramagnetic resonance towards hydroxyl radical (root OH), superoxide
anion radical (), methoxy radical (root CH2OH), carbon-dioxide anion
radical (), as well as towards nitric-oxide radical (root NO) and
2,2-diphenyl-1-picrylhydrazyl (root DPPH) radical. It reduced the
production of all tested radicals showing more promising activity
against , root CH2OH and root DPPH radicals (56\%, 50\% and 48\%,
respectively) in comparison with root NO, and root OH radicals (38\%,
23\% and 15\%, respectively). The antimicrobial activity of phytol was
evaluated by the microdilution method against eight bacterial and eight
fungal strains. To varying degrees, it was proven to be active against
all tested bacteria and fungi (MIC 0.003-0.038mg/mL and MBC
0.013-0.052mg/mL, MIC 0.008-0.016mg/mL and MFC 0.090-0.520mg/mL,
respectively). According to the obtained results, medical foods
containing phytol may support development of new therapies for heart
disease.
Keywords:
reactive oxygen and nitrogen species; medical foods; microorganisms; phytolSource:
Natural Product Research, 2014, 28, 6, 372-376
DOI: 10.1080/14786419.2013.869692
ISSN: 1478-6427