COPPER-INDUCED CHANGES OF LIPID PEROXIDATION AND HEMATO-BIOCHEMICAL PARAMETERS IN RAT BLOOD: PROTECTIVE ROLE OF FLAVONOIDS
2014
Аутори:
Mladenovic, Jelena M.Paunovic, Milica G.
Matic, Milos M.
Knezevic, Veroljub S.
Ognjanovic, Branka I.
Štajn, Andraš Š.
Saičić, Zorica
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The effects of subchronic exposure to copper (Cu) on lipid peroxidation,
hemato-biochemical parameters, and the possible protective role of
flavonoids Quercetin and (-)-Epicatechin were studied. Male Wistar
albino rats were treated with Cu (560 mg/L, p.o. as CuCl2 center dot
2H(2)O for 5 weeks) and Quercetin and (-)-Epicatechin (40 mg/kg BW each,
i.p., every third day during the last 3 weeks) alone or in combination.
Cu increased the concentration of lipid peroxides, decreased the number
of erythrocytes, hemoglobin and hematocrit values and increased the
activities of aspartate aminotransferase, alanine aminotransferase and
lactate dehydrogenase. Coadministration of Quercetin and (-)-Epicatechin
with Cu lowered the process of lipid peroxidation and restored examined
hemato-biochemical parameters to control values. Our results indicate
that Cu induced oxidative damage in erythrocytes, which led to anemia,
while Quercetin and (-)-Epicatechin showed a protective effect on the
hemato-biochemical processes in the blood of rats.
Кључне речи:
Copper; erythrocyte; flavonoids; hematological parameters; biochemical parameters; lipid peroxidationИзвор:
Archives of Biological Sciences, 2014, 66, 3, 1271-1279
DOI: 10.2298/ABS1403271M
ISSN: 1821-4339