Bioactive composition, antimicrobial activities and the influence of Agrocybe aegerita (Brig.) Sing on certain quorum-sensing-regulated functions and biofilm formation by Pseudomonas aeruginosa
2014
Autori:
Petrović, JovanaGlamočlija, Jasmina
Stojković, Dejan
Nikolić, Miloš
Ćirić, Ana
Fernandes, Angela
Ferreira, Isabel C. F. R.
Soković, Marina
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2014 Royal Society of Chemistry
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Agrocybe aegerita (Brig.) Sing is a basidiomycete, white rot fungus.
Antimicrobial activities and the antiqourum effect on Pseudomonas
aeruginosa of an A. aegerita methanolic extract were investigated. The
extract showed very good antimicrobial activity against all the tested
microorganisms in a dose dependent manner. Effects of the Sub-MIC, MIC
and 2MIC of the A. aegerita methanolic extract regulated the virulence
factors in the quorum sensing (QS) test, as well as biofilm formation on
P. aeruginosa. Sub-inhibitory and inhibitory concentrations of the
extract demonstrated the reduction of virulence factors such as
pyocyanin production, twitching and swimming motility. The biofilm
forming capability of P. aeruginosa PAO1 was also reduced in a
concentration-dependent manner. Furthermore, the chemical composition of
the methanolic extract was determined considering its phenolic
composition. The methanolic extract of A. aegerita can be a very good
source of bioactive substances. This research is of great importance due
to the prevalence of drug-resistant microorganisms.
Izvor:
Food & Function, 2014, 5, 12, 3296-3303Finansiranje / projekti:
- Karakterizacija i primena metabolita gljiva i utvrđivanje potencijala novih biofungicida (RS-MESTD-Basic Research (BR or ON)-173032)
- Foundation for Science and Technology (SFRH/BD/76019/2011)
DOI: 10.1039/c4fo00819g
ISSN: 2042-650X