Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats
2014
Authors:
Vojnović-Milutinović, DanijelaRadovanović, Marina
Dinic, Jovana
Đorđević, Ana
Velickovic, Natasa
Elaković, Ivana
Matić, Gordana
Brkljačić, Jelena
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Alterations in leptin and glucocorticoid signaling pathways in the
hypothalamus of male and female rats subjected to a fructose-enriched
diet were studied. The level of expression of the key components of the
leptin signaling pathway (neuropeptide Y /NPY/ and suppressor of
cytokine signaling 3 /SOCS3/), and the glucocorticoid signaling pathway
(glucocorticoid receptor /GR/, 11 beta-hydroxysteroid dehydrogenase type
1 /11 beta HSD1/ and hexose-6-phosphate dehydrogenase /H6PDH/) did not
differ between fructose-fed rats and control animals of both genders.
However, in females, a fructose-enriched diet provoked increases in the
adiposity index, plasma leptin and triglyceride concentrations, and
displayed a tendency to decrease the leptin receptor (ObRb) protein and
mRNA levels. In male rats, the fructose diet caused elevations in plasma
non-esterified fatty acids and triglycerides, as well as in both plasma
and hypothalamic leptin concentrations. Our results suggest that a
fructose-enriched diet can induce hyperleptinemia in both female and
male rats, but with a more pronounced effect on hypothalamic leptin
sensitivity in females, probably contributing to the observed
development of visceral adiposity.
Keywords:
Fructose diet; hypothalamus; leptin; leptin receptor; glucocorticoids; glucocorticoid receptorSource:
Archives of Biological Sciences, 2014, 66, 2, 829-839
DOI: 10.2298/ABS1402829M
ISSN: 1821-4339