dc.creator | Pejin, Boris | |
dc.creator | Talevska, Aleksandra | |
dc.creator | Ćirić, Ana | |
dc.creator | Glamočlija, Jasmina | |
dc.creator | Nikolić, Miloš | |
dc.creator | Talevski, Trajce | |
dc.creator | Soković, Marina | |
dc.date.accessioned | 2016-05-23T11:00:43Z | |
dc.date.available | 2016-05-23T11:00:43Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1478-6427 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2274 | |
dc.description.abstract | The anti-quorum sensing activities towards the bacterium Pseudomonas
aeruginosa PA01 (pyocyanin production, biofilm formation and twitching
and flagella motility) of two crude extracts (methanol and acetone) of
the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) were
evaluated in vitro for the first time. Both extracts demonstrated P.
aeruginosa pyocyanin inhibitory activity, reducing its production for
49.90\% and 42.44\%, respectively. In addition, they both showed higher
anti-biofilm activity (48.29\% and 53.99\%, respectively) than
ampicillin (30.84\%). Finally, O. rotunda extracts effectively reduced
twitching and flagella motility of P. aeruginosa. Taken all together,
these results suggest that endemic sponge species from the oldest lake
in Europe may offer novel bioactive natural products with promising
medicinal potential towards P. aeruginosa infections. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of the
Republic of Serbia {[}172053, 173032] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Research | |
dc.subject | Lake Ohrid | |
dc.subject | Porifera | |
dc.subject | Ochridaspongia rotunda | |
dc.subject | bioactivity | |
dc.title | Anti-quorum sensing activity of selected sponge extracts: a case study
of Pseudomonas aeruginosa | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Талевски, Трајце; Ћирић, Aна Д.; Талевска, Aлександра; Соковић, Марина Д.; Николиц, Милос; Гламочлија, Јасмина; Пејин, Борис; | |
dc.citation.issue | 24 | |
dc.citation.volume | 28 | |
dc.identifier.doi | 10.1080/14786419.2014.934239 | |
dc.identifier.scopus | 2-s2.0-84908662200 | |
dc.identifier.wos | 000342326700016 | |
dc.citation.spage | 2330 | |
dc.citation.epage | 2333 | |
dc.type.version | publishedVersion | en |