Long-term effects of somatostatin 14 on the pituitary-ovarian axis in rats
2014
Аутори:
Nestorović, NatašaManojlović-Stojanoski, Milica
Trifunović, Svetlana
Ristić, Nataša
Filipović, Branko
Šošić-Jurjević, Branka
Milošević, Verica
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2014 by the Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences
Метаподаци
Приказ свих података о документуАпстракт:
The long-term effects of somatostatin 14 (SST-14) on the
pituitary-ovarian axis were examined. Female Wistar rats received 20 mu
g/100 g b.w. doses subcutaneously twice daily for 5 consecutive days in
the infantile (from 1lth to 15th day) or peripubertal (from 33rd to 37th
day) period of life. Females treated as infants were killed in the
peripubertal (38th day) or adult period of life (80th day), and those
treated during peripuberty as adults (80th day). Pituitary
follicle-stimulating (FSH), luteinizing (LH) and somatotropic (GH)
cells, and ovaries were analyzed by stereology and morphometry. Serum
FSH and LH concentrations were determined by RTA. FSH and LH cell
volumes were significantly decreased in pituitaries of peripubertal
females treated with SST-14 as infants, and in adult females treated
during peripuberty. GH cell volume was decreased in all treated rats. In
the ovaries, enlargement of the non-growing pool of follicles was
detected in adult females treated during peripuberty. SST-14 applied to
infant rats did not lead to changes in initial follicular recruitment,
but it disturbed follicle growth and development at later stages. It can
be concluded that SST-14 exerted long-term inhibitory effects on the
pituitary-ovarian axis and GH cells in rats.
Кључне речи:
Gonadotropic cells; Somatotropic cells; Ovary; Folliculogenesis; StereologyИзвор:
General Physiology and Biophysics, 2014, 33, 2, 157-168
DOI: 10.4149/gpb_2014001
ISSN: 0231-5882