dc.creator | Nikodinovic-Runic, Jasmina | |
dc.creator | Mojić, Marija | |
dc.creator | Kang, Yijin | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Mijatović, Sanja | |
dc.creator | Vasiljevic, Branka | |
dc.creator | Stamenkovic, Vojislav R. | |
dc.creator | Senerovic, Lidija | |
dc.date.accessioned | 2016-05-23T11:00:46Z | |
dc.date.available | 2016-05-23T11:00:46Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 2050-7518 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2288 | |
dc.description.abstract | Bacterial pigment undecylprodigiosin (UP) was produced using
Streptomyces sp. JS520 and conjugated to monodisperse gold nanoparticles
(UP-Au). Both UP and UP-Au showed cytocidal activity towards melanoma
(A375), lung carcinoma (A549), breast cancer (MCF-7) and colon cancer
(HCT-116) cells, inducing apoptosis with IC50 values ranging from 0.4 to
4 mu g ml(-1). Unconjugated UP had a tendency to lose its activity over
time and to change biophysical characteristics over pH. The loss of the
pigment potency was overcome by conjugation with gold nanoparticles.
UP-Au exhibited high stability over pH 3.8 to 7.4 and its activity
remained unaffected in time. Nano-packing changed the mechanism of UP
toxicity by converting the intracellular signals from a mitochondrial
dependent to a mitochondrial independent apoptotic process. The
availability of nonpyrogenic UP in high amounts, together with specific
anticancer activity and improved stability in the complex with gold
nanoparticles, presents a novel platform for further development of
UP-Au complexes as an anticancer drug suitable for clinical
applications. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of Serbia
{[}173048, 173013]; U.S. Department of Energy, Office of Science, Office
of Basic Energy Sciences {[}DE-AC02-06CH11357] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Journal of Materials Chemistry B | |
dc.title | Undecylprodigiosin conjugated monodisperse gold nanoparticles
efficiently cause apoptosis in colon cancer cells in vitro | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Никодиновиц-Руниц, Јасмина; Мијатовић, Сања A.; Стаменковиц, Војислав Р.; Сенеровиц, Лидија; Канг, Yијин; Мојић, Марија К.; Максимовић, Данијела Д.; Васиљевиц, Бранка; | |
dc.citation.issue | 21 | |
dc.citation.volume | 2 | |
dc.identifier.doi | 10.1039/c4tb00300d | |
dc.identifier.scopus | 2-s2.0-84899954515 | |
dc.identifier.wos | 000336072400012 | |
dc.citation.spage | 3271 | |
dc.citation.epage | 3281 | |
dc.type.version | publishedVersion | en |