Efekat maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova posle intoksikacije kadmijumom
Effect of olive oil on antioxidative defense components in liver of cadmium intoxicated rats
Authors:
Ognjanović, Branka I.Maletić, Snežana D.
Pavlović, Slađan
Žikić, Radoslav V.
Štajn, Andraš Š.
Radojičić, Ratko M.
Saičić, Zorica
Document Type:
Article (Published version)
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The present study investigated the possible protective role of olive oil on antioxidative defense components in liver of cadmium (Cd) intoxicated animals. Male, Wistar albino 3 months old rats were injected with a single dose of: 1) CdCl2 (0.4 mg Cd/kg i.p. and sacrificed after 24h), 2) olive oil (0.4 ml olive oil/kg b.m., i.m., 48h before the sacrificing) and 3) olive oil + Cd (in above mentioned amounts). Treatment with Cd increased lipid peroxidation (LP) in blood and activities of alanine and aspartate transaminase (ALT and AST) in plasma. Concentrations of non enzymatic components of antioxidative defense system (AOS): vitamin C (Vit C) and vitamin E (Vit E) were significantly decreased in liver tissue of Cd treated rats. Pretreatment with olive oil reversed Cd induced alterations in LP content and transaminases activities, as well as on endogenous antioxidive defense components.