Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment
2016
Authors:
Spasojević, DragicaZmejkoski, Danica
Glamočlija, Jasmina
Nikolić, Miloš
Soković, Marina
Milošević, Verica
Jarić, Ivana
Stojanović, Marijana
Marinković, Emilija
Barisani-Asenbauer, Talin
Prodanović, Radivoje
Jovanović, Miloš
Radotić, Ksenija
Document Type:
Article (Published version)
,
© 2016 Elsevier B.V. and International Society of Chemotherapy
Metadata
Show full item recordAbstract:
Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP−Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.
Keywords:
Lignin model polymer; Alginate; Antimicrobial activity; Bacterial biofilm; Wound treatmentSource:
International Journal of Antimicrobial Agents, 2016, 48, 6, 732-735Funding / projects:
- Allergens, antibodies, enzymes and small physiologically important molecules: design, structure, function and relevance (RS-MESTD-Basic Research (BR or ON)-172049)
- Study of structure-function relationships in the plant cell wall and modifications of the wall structure by enzyme engineering (RS-MESTD-Basic Research (BR or ON)-173017)
- Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-MESTD-Basic Research (BR or ON)-173032)
- info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/III45012/RS// (RS-MESTD-Basic Research (BR or ON)-III45012)
DOI: 10.1016/j.ijantimicag.2016.08.014
ISSN: 0924-8579
PubMed: 27742207
WoS: 000389520700024
Scopus: 2-s2.0-85000995852
URI
http://linkinghub.elsevier.com/retrieve/pii/S0924857916302679https://www.scopus.com/record/display.uri?eid=2-s2.0-85000995852&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=5EA0B882AD39CF37A9F768C8B10917B5.wsnAw8kcdt7IPYLO0V48gA%3A1#
https://radar.ibiss.bg.ac.rs/handle/123456789/2480