Lipid accumulation product as a marker of cardiometabolic susceptibility in women with different phenotypes of polycystic ovary syndrome
2016
Authors:
Božić-Antić, IvanaIlić, Dušan
Bjekić-Macut, Jelica
Bogavac, Tamara
Vojnović-Milutinović, Danijela
Kastratovic-Kotlica, Biljana
Milić, Nataša
Stanojlović, Olivera
Andrić, Zoran
Macut, Djuro
Document Type:
Article (Published version)
,
© 2016 European Society of Endocrinology
Metadata
Show full item recordAbstract:
Objective: There are limited data on cardiometabolic risk factors and the prevalence of metabolic syndrome (MetS) across the different PCOS phenotypes in Caucasian population. Lipid accumulation product (LAP) is a clinical surrogate marker that could be used for evaluation of MetS in clinical practice. The aim of the study was to analyze metabolic characteristics and the ability of LAP to predict MetS in different PCOS phenotypes. Design: Cross-sectional clinical study analyzing 365 women with PCOS divided into four phenotypes according to the ESHRE/ASRM criteria, and 125 healthy BMI-matched controls. Methods: In all subjects, LAP was determined and MetS was diagnosed according to the National Cholesterol Education Program/Adult Treatment Panel III (NCEP-ATP III), the International Diabetes Federation (IDF) and the Joint Interim Statement (JIS) criteria. Logistic regression and ROC curve analyses were used to determine predictors of MetS in each PCOS phenotype. All analyses were performed with age and BMI adjustment. Results: All PCOS phenotypes in comparison to controls had higher prevalence of MetS assessed by NCEP-ATP III criteria, and only classic phenotypes when IDF and JIS criteria were used. All phenotypes had the same prevalence of MetS irrespective of used definition. LAP and exhibited the highest diagnostic accuracy and was an independent predictor of MetS in all phenotypes. Conclusion: LAP is an independent and accurate clinical determinant of MetS in all PCOS phenotypes in our Caucasian population. All PCOS phenotypes, including non-classic ones, are metabolically challenged and with cardiovascular risk, particularly phenotype B.
Source:
European Journal of Endocrinology, 2016, 175, 6, 551-560Funding / projects:
- The development of animal models of epilepsy and testing convulsive and anticonvulsive substances (RS-MESTD-Basic Research (BR or ON)-175032)
- Role of steroid hormones in neuroendocrine adaptation to stress and pathophysiology of metabolic syndrome - molecular mechanisms and clinical implications (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41009)
DOI: 10.1530/EJE-16-0775
ISSN: 0804-4643
PubMed: 27634940
WoS: 000386915600012
Scopus: 2-s2.0-85000384361
URI
http://www.eje-online.org/lookup/doi/10.1530/EJE-16-0775https://www.scopus.com/record/display.uri?eid=2-s2.0-85000384361&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=691E27A4B52E4CB98111082A19AFDEEC.wsnAw8kcdt7IPYLO0V48gA%3A9#
https://radar.ibiss.bg.ac.rs/handle/123456789/2482