An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1.
2017
Authors:
Pejin, BorisĆirić, Ana
Dimitrić Marković, Jasmina
Glamočlija, Jasmina
Nikolić, Miloš
Soković, Marina
Document Type:
Article (Published version)
,
© 2016 Informa UK Limited, trading as Taylor & Francis Group
Metadata
Show full item recordAbstract:
Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25 μg/mL) being the most active (43%). In comparison, ampicillin (c 93.75 μg/mL) and streptomycin (c 21.25 μg/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225 μg/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.
Keywords:
Flavanone-7-O-glucoside; Anti-biofilm activity; Bacterial resistance; Delphinidin; Infectious diseases; Low sub-MICSource:
Natural product research, 2017, 31, 10, 1177-1180Funding / projects:
- Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-MESTD-Basic Research (BR or ON)-173032)
DOI: 10.1080/14786419.2016.1222386
ISSN: 1478-6419
PubMed: 27539815
WoS: 000395151500011
Scopus: 2-s2.0-84982276502
URI
https://www.tandfonline.com/doi/full/10.1080/14786419.2016.1222386http://www.ncbi.nlm.nih.gov/pubmed/27539815
https://radar.ibiss.bg.ac.rs/handle/123456789/2623