Purine nucleoside analogs in the therapy of cancer and neuroinflammation
2015
Authors:
Savić, DanijelaStanković, Tijana
Lavrnja, Irena
Podolski-Renić, Ana
Banković, Jasna
Peković, Sanja
Stojiljković, Mirjana
Rakić, Ljubisav
Ruždijić, Sabera
Pešić, Milica
Document Type:
Review (Published version)
Metadata
Show full item recordAbstract:
Purine nucleoside analogs have been in clinical use for almost 50 years. At the beginning developed as antiviral agents, later their efficacy was demonstrated in cancer treatment, especially hematological malignances. The approval of new purine nucleoside analogs by US Food and Drug Administration (FDA) over the past decade implies that the interest for these drugs still exists. Here, we review new nucleoside analogs that are currently in preclinical or clinical development as anticancer agents. In addition, we highlight the potential for implementation of these drugs in other pathological conditions, particularly in neuroinflammation.
Keywords:
Purine nucleoside analogs; Cancer; Neuroinflammation; Brain injurySource:
Molecular inhibitors in targeted therapy, 2015, 1, 1, 3-14Funding / projects:
- Cellular and molecular basis of neuroinflamation: potential targets for translational medicine and therapy (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41014)
- Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41031)
URI
http://www.degruyter.com/view/j/motth.2015.1.issue-1/motth-2015-0002/motth-2015-0002.xmlhttps://radar.ibiss.bg.ac.rs/handle/123456789/2633