Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines
2017
Аутори:
Ljujić, MilaMijatović, Sanja
Bulatović, Mirna
Mojić, Marija
Maksimović-Ivanić, Danijela
Radojković, Dragica
Topić, Aleksandra
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2016, Arányi Lajos Foundation
Метаподаци
Приказ свих података о документуАпстракт:
Increased circulating alpha-1-antitrypsin (AAT) correlates with cancer stage/aggressiveness, but its role in cancer biology is unclear. We revealed antagonistic effect of AAT to cisplatin-induced cytotoxicity in prostate (PC3) and melanoma (A375) cancer cell lines. Moreover, AAT abrogated cytotoxicity of MEK inhibitor U0126 in PC3 cell line. Weaker antagonistic effect of AAT on cytotoxicity of PI3/Akt and NF-kB inhibitors was also observed. In addition, cisplatin increased AAT gene expression in transfected PC3 cells. However, AAT derived from transfected PC3 cells did not antagonize cisplatin-induced cytotoxicity. In conclusion, these results suggest possible association between high circulating AAT and cisplatin resistance.
Кључне речи:
Alpha-1-antitrypsin; Cisplatin; Melanoma cancer; Prostate cancerИзвор:
Pathology & Oncology Research, 2017, 23, 2, 335-343Финансирање / пројекти:
- Молекуларни механизми физиолошке и фармаколошке контроле инфламације и канцера (RS-MESTD-Basic Research (BR or ON)-173013)
- Комплексне болести као модел систем за проучавање модулације фенотипа-структурна и функционална анализа молекуларних биомаркера (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.1007/s12253-016-0104-3
ISSN: 1219-4956
PubMed: 27617337
WoS: 000399000200014
Scopus: 2-s2.0-85016626907
URI
http://link.springer.com/10.1007/s12253-016-0104-3https://radar.ibiss.bg.ac.rs/handle/123456789/2729