Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines
2017
Autori:
Ljujić, MilaMijatović, Sanja
Bulatović, Mirna
Mojić, Marija
Maksimović-Ivanić, Danijela
Radojković, Dragica
Topić, Aleksandra
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2016, Arányi Lajos Foundation
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Increased circulating alpha-1-antitrypsin (AAT) correlates with cancer stage/aggressiveness, but its role in cancer biology is unclear. We revealed antagonistic effect of AAT to cisplatin-induced cytotoxicity in prostate (PC3) and melanoma (A375) cancer cell lines. Moreover, AAT abrogated cytotoxicity of MEK inhibitor U0126 in PC3 cell line. Weaker antagonistic effect of AAT on cytotoxicity of PI3/Akt and NF-kB inhibitors was also observed. In addition, cisplatin increased AAT gene expression in transfected PC3 cells. However, AAT derived from transfected PC3 cells did not antagonize cisplatin-induced cytotoxicity. In conclusion, these results suggest possible association between high circulating AAT and cisplatin resistance.
Ključne reči:
Alpha-1-antitrypsin; Cisplatin; Melanoma cancer; Prostate cancerIzvor:
Pathology & Oncology Research, 2017, 23, 2, 335-343Finansiranje / projekti:
- Molekularni mehanizmi fiziološke i farmakološke kontrole inflamacije i kancera (RS-MESTD-Basic Research (BR or ON)-173013)
- Kompleksne bolesti kao model sistem za proučavanje modulacije fenotipa-strukturna i funkcionalna analiza molekularnih biomarkera (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.1007/s12253-016-0104-3
ISSN: 1219-4956
PubMed: 27617337
WoS: 000399000200014
Scopus: 2-s2.0-85016626907
URI
http://link.springer.com/10.1007/s12253-016-0104-3https://radar.ibiss.bg.ac.rs/handle/123456789/2729