Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp. viridis Bark
2017
Аутори:
Novaković, MiroslavNikodinović-Runić, Jasmina
Veselinović, Jovana
Ilić-Tomić, Tatjana
Vidaković, Vera
Tešević, Vele
Milosavljević, Slobodan
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2017 The American Chemical Society and American Society of Pharmacognosy
Метаподаци
Приказ свих података о документуАпстракт:
Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of cancer cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and IIα for an in silico investigation.
Финансирање / пројекти:
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-MESTD-Basic Research (BR or ON)-172053)
- Изучавање микробиолошког диверзитета и карактеризација корисних срединских микроорганизама (RS-MESTD-Basic Research (BR or ON)-173048)
У:
- Journal of Natural Products (2017), 80(5): 1255-1263
DOI: 10.1021/acs.jnatprod.6b00805
ISSN: 0163-3864
PubMed: 28368586
WoS: 000402498300004
Scopus: 2-s2.0-85019767389
URI
http://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.6b00805https://radar.ibiss.bg.ac.rs/handle/123456789/2765