Rani elektrofiziološki znaci poremećaja spavanja i motorne kontrole u starenju pacova sa neurodegeneracijom holinergičkih neurona
Early electrophysiological markers of the sleep and motor control disorders during aging in rats with neurodegeneration of the cholinergic neurons
Abstract:
The aim of the present doctoral dissertation was to evaluate the impact
of aging during sleep in the rat models of Alzheimer’s and Parkinson’s disease
cholinergic neuropathology, and to determine the possible different and earlier
onset of age-related sleep disorder during healthy aging and aging with the
neurodegenerative diseases.
We used the bilateral nucleus basalis (NB) and nucleus pedunculopontinus
tegmentalis (PPT) lesioned rats as the in vivo models of functionally distinct
cholinergic neuropathology, and we followed the impact of aging on sleep
architecture, the electroencephalographic (EEG) microstructure and motor
control across sleep/wake states.
We evidenced the topographically distinct impact of healthy aging on
sleep architecture and motor control within the sensorimotor (SMCx) vs. motor
cortex (MCx). Whereas healthy aging consistently altered only the SMCx sleep
architecture, it increased the delta and beta cortical drives from both cortices
during Wake, but only through the MCx drive during rapid eye movement
sleep (REM).
Our results have shown for the first time that the earliest signs of aging
during distinct cholinergic neuropathology were expressed through a different
and topographically specific EEG microstructure during REM. EEG delta
amplitude attenuation within the SMCx was the earliest sign of aging in the NB
lesion, whereas EEG sigma amplitude augmentation within the MCx was the
earliest sign of aging in the PPT lesion during REM. In addition, aging was
differently expressed through the SMCx drive alterations, but it was commonly
expressed through the MCx drive alterations during all sleep/wake states.
This doctoral dissertation provided for the first time an evidence of
distinct REM sleep disorders and sleep state related cortical drives as the signs
of aging onset during functionally distinct cholinergic neuropathologies.
Keywords:
Aging; Sleep; Motor control; Neurodegenerative diseases; Corticomuscular coherence (CMC); Nucleus basalis (NB); Nucleus pedunculopontinus tegmentalis (PPT); Cholinergic neuronal loss; Electroencephalography (EEG); Electromyography (EEG)Funding / projects:
- Neurobiology of sleep in aging and disease - electroencephalographic markers and modeling in the estimation of disorder (RS-MESTD-Basic Research (BR or ON)-173022)
In:
- University of Belgrade, Faculty of Biology (2017)
URI
http://uvidok.rcub.bg.ac.rs/handle/123456789/1886https://radar.ibiss.bg.ac.rs/handle/123456789/2801