Antiproliferative activity of ruthenium(ii) arene complexes with mono- and bidentate pyridine-based ligands
2016
Autori:
Richter, StefanSingh, Sushma
Drača, Dijana
Kate, Anup
Kumbhar, Anupa
Kumbhar, Avinash S.
Maksimović-Ivanić, Danijela
Mijatović, Sanja
Lönnecke, Peter
Hey-Hawkins, Evamarie
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© The Royal Society of Chemistry 2016
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
A series of Ru(II) arene complexes of mono- and bidentate N-donor ligands with carboxyl or ester groups and chlorido ancillary ligands were synthesised and structurally characterised. The complexes have a distorted tetrahedral piano-stool geometry. The binding interaction was studied with calf thymus DNA (CT-DNA) by absorption titration, viscosity measurement, thermal melting, circular dichroism, ethidium bromide displacement assay and DNA cleavage of plasmid DNA (pBR322), investigated by gel electrophoresis. The dichlorido complexes bind covalently to DNA in the dark, similar to cisplatin, while the monochlorido complexes bind covalently on irradiation, similar to cisplatin analogues. The compounds are selectively cytotoxic against several tumour cell lines and show specific nonlinear correlation between dose and activity. This phenomenon is closely related to their potential to act preferentially as inhibitors of cell division.
Izvor:
Dalton Transactions, 2016, 45, 33, 13114-13125Finansiranje / projekti:
- Molekularni mehanizmi fiziološke i farmakološke kontrole inflamacije i kancera (RS-MESTD-Basic Research (BR or ON)-173013)
- Free State of Saxony (project number 100099597)
- Graduate School “Leipzig School of Natural Sciences–Building with Molecules and Nano-objects” (BuildMoNa)
- Indo-German research project (INT/ FRG/DAAD/P-225/2013)
DOI: 10.1039/c6dt01782g
ISSN: 1477-9226
PubMed: 27264161
WoS: 000382135400019
Scopus: 2-s2.0-84983334421
URI
http://xlink.rsc.org/?DOI=C6DT01782Ghttp://www.ncbi.nlm.nih.gov/pubmed/27264161
https://radar.ibiss.bg.ac.rs/handle/123456789/2847