Naturally occurring compounds in differentiation based therapy of cancer.
2018
Authors:
Mijatović, SanjaBramanti, Alessia
Nicoletti, Ferdinando
Fagone, Paolo
Kaluđerović, Goran N.
Maksimović-Ivanić, Danijela
Document Type:
Article (Accepted Version)
,
© 2018 Elsevier Inc.
Metadata
Show full item recordAbstract:
Differentiation of cancer cells entails the reversion of phenotype from malignant to the original. The conversion to cell type characteristic for another tissue is named transdifferentiation. Differentiation/transdifferentiation of malignant cells in high grade tumor mass could serve as a nonaggressive approach that potentially limits tumor progression and augments chemosensitivity. While this therapeutic strategy is already being used for treatment of hematological cancers, its feasibility for solid malignancies is still debated. We will presently discuss the natural compounds that show these properties, with focus on anthraquinones from Aloe vera, Senna, Rheum sp. and hop derived prenylflavonoids.
Keywords:
Aloe emodin; Blood tumors; Brain tumors; Cancer; Chemotherapy; Differentiation based therapies; Isoxanthohumol; Naturally occurring compounds; Neurooncology; Solid tumors; TransdifferentiationSource:
Biotechnology Advances, 2018Funding / projects:
- Molecular mechanisms of physiological and pharmacological control of inflammation and cancer (RS-MESTD-Basic Research (BR or ON)-173013)
- IRCCS Centro Neurolesi “Bonino Pulejo”, Messina-Italy
DOI: 10.1016/j.biotechadv.2018.04.001
PubMed: 29656090
WoS: 000443662700005
Scopus: 2-s2.0-85045557392
URI
http://linkinghub.elsevier.com/retrieve/pii/S0734975018300739http://www.ncbi.nlm.nih.gov/pubmed/29656090
https://radar.ibiss.bg.ac.rs/handle/123456789/3045