Can Oxidation-Reduction Potential of Cerebrospinal Fluid Be a Monitoring Biomarker in Amyotrophic Lateral Sclerosis?
2018
Autori:
Opačić, MilošStević, Zorica
Baščarević, Vladimir
Živić, Miroslav
Spasić, Mihajlo
Spasojević, Ivan
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2018, Mary Ann Liebert, Inc. 2018.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The monitoring of progression in amyotrophic lateral sclerosis (ALS) relies on clinical outcome measures that take months to interpret, such as revised ALS functional rating scale (ALSFRS-R) score, with no approved biomarkers. A number of clinical studies have documented the involvement of oxidative stress in ALS pathology. Pertinent to this, we propose to evaluate oxidation-reduction potential (ORP) of cerebrospinal fluid (CSF) as a potential indicator of ALS progression. The case-control study included 24 patients with neurological non-neurodegenerative disorders (controls) and 82 ALS patients with different degrees of disease (ALSFRS-R score: 21-47). ORP was significantly higher in ALS patients than controls. It was not dependent on age or gender. A strong negative correlation was found between ORP and ALSFRS-R score for all patients and patients with spinal onset. In other words, ORP increased with ALS progression. No correlation was found for the subset of patients with bulbar onset, most likely because of the physical distance between neurodegenerative loci and the site of CSF collection. These results lead to the hypothesis that ORP of CSF has a potential as monitoring biomarker in ALS, particularly in the cohort of patients with spinal onset. Antioxid. Redox Signal. 28, 1570-1575.
Ključne reči:
Amyotrophic lateral sclerosis; Biomarker; Cerebrospinal fluid; Oxidative stress; ProgressionIzvor:
Antioxidants and Redox Signaling, 2018, 28, 17, 1570-1575Finansiranje / projekti:
- Ćelijska i molekulska osnova neuroinflamacije: potencijala ciljna mesta za translacionu medicinu i terapiju (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41014)
- Molekularni mehanizmi redoks signalinga u homeostazi, adaptaciji i patologiji (RS-MESTD-Basic Research (BR or ON)-173014)
DOI: 10.1089/ars.2017.7433
PubMed: 29113448
WoS: 000417814300001
Scopus: 2-s2.0-85046633968
URI
http://www.liebertpub.com/doi/10.1089/ars.2017.7433https://radar.ibiss.bg.ac.rs/handle/123456789/3065