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Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction.
dc.creator | Garcia, Catarina | |
dc.creator | Silva, Catarina Oliveira | |
dc.creator | Monteiro, Carlos M | |
dc.creator | Nicolai, Marisa | |
dc.creator | Viana, Ana | |
dc.creator | Andrade, Joana M | |
dc.creator | Barasoain, Isabel | |
dc.creator | Stanković, Tijana | |
dc.creator | Quintana, José | |
dc.creator | Hernández, Inmaculada | |
dc.creator | González, Ignacio | |
dc.creator | Estévez, Francisco | |
dc.creator | Díaz-Lanza, Ana M | |
dc.creator | Reis, Catarina P | |
dc.creator | Afonso, Carlos AM | |
dc.creator | Pešić, Milica | |
dc.creator | Rijo, Patrícia | |
dc.date.accessioned | 2018-06-22T07:39:44Z | |
dc.date.available | 2018-06-22T07:39:44Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | https://www.future-science.com/doi/10.4155/fmc-2017-0239 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3086 | |
dc.description.abstract | AIM 6,7-dehydroroyleanone (DHR) is a cytotoxic abietane present in the essential oil of Plectranthus madagascariensis. METHODS/RESULTS Different extraction parameters were tested, and its extraction optimization was accomplished with a Clevenger apparatus-based hydrodistillation. After isolation, its effect on microtubules, P-glycoprotein and caspases was assessed on several cell lines and the compound was coupled with hybrid nanoparticles. The results show that DHR does not interfere with microtubule formation, but evades the resistance mechanisms of P-glycoprotein. Strong activation of caspases-3 and -9 indicates that DHR is able to induce apoptosis by triggering the intrinsic cell death pathway. Moreover, the assembly of DHR with hybrid nanoparticles was able to potentiate the effect of DHR in cancer cells. CONCLUSION DHR seems to be a promising starting material with anticancer properties to further be explored. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS// | |
dc.relation | Fundação para a Ciência e a Tecnologia | |
dc.rights | restrictedAccess | |
dc.source | Future Medicinal Chemistry | |
dc.subject | 6,7-dehydroroyleanone | |
dc.subject | Plectranthus | |
dc.subject | cytotoxicity | |
dc.subject | extraction | |
dc.subject | isolation | |
dc.subject | multidrug resistance | |
dc.subject | nanotechnology | |
dc.title | Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Гарциа, Цатарина; Силва, Цатарина Оливеира; Монтеиро, Царлос М; Ницолаи, Мариса; Виана, Aна; Aндраде, Јоана М; Барасоаин, Исабел; Qуинтана, Јосé; Хернáндез, Инмацулада; Гонзáлез, Игнацио; Естéвез, Францисцо; Пешић, Милица; Дíаз-Ланза, Aна М; Реис, Цатарина П; Aфонсо, Царлос AМ; Ријо, Патрíциа; Станковић, Тијана; | |
dc.rights.holder | © 2018 Newlands Press | |
dc.citation.issue | 10 | |
dc.citation.volume | 10 | |
dc.identifier.doi | 10.4155/fmc-2017-0239 | |
dc.identifier.pmid | 29749759 | |
dc.identifier.scopus | 2-s2.0-85048107643 | |
dc.identifier.wos | 000433568500005 | |
dc.citation.apa | Garcia, C., Silva, C. O., Monteiro, C. M., Nicolai, M., Viana, A., Andrade, J. M., … Rijo, P. (2018). Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction. Future Medicinal Chemistry, 10(10), 1177–1189. | |
dc.citation.vancouver | Garcia C, Silva CO, Monteiro CM, Nicolai M, Viana A, Andrade JM, Barasoain I, Stankovic T, Quintana J, Hernández I, González I, Estévez F, Díaz-Lanza AM, Reis CP, Afonso CA, Pesic M, Rijo P. Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction. Future Med Chem. 2018;10(10):1177–89. | |
dc.citation.spage | 1177 | |
dc.citation.epage | 1189 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 |
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