Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae)
2018
Autori:
Nenadić, MarijaSoković, Marina
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Ćirić, Ana
Vesović, Nikola
Ćurčić, Srećko
Tip dokumenta:
Članak u časopisu (Recenzirana verzija)
,
© 2018 Institute of Zoology, Slovak Academy of Sciences
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Inhibition of the proliferation of human tumour cells and porcine non-tumour cells by the pygidial gland secretion released by adults of four ground beetle species was observed in this study. The sulphorhodamine B (SRB) assay was applied to establish the percentages of inhibition of the net growth of four human tumour cell lines and porcine liver primary non-tumour cells. The secretions of all tested ground beetle species were shown to have an antiproliferative effect on the tested cell lines. Special emphasis is put on the secretion of Abax parallelepipedus, which showed the highest antitumour potential and weakest inhibition of non-tumour cell proliferation. The antitumour and antiproliferative potential of the pygidial gland secretions of ground beetles is here demonstrated for the first time. It is suggested that certain organic acids are responsible for the action. Further investigation needs to be conducted in order to better understand the mechanisms governing the observed cytotoxic and antitumour activity.
Napomena:
This is a post-peer-review, pre-copyedit version of an article published in Biologia. The final authenticated version is available online at: http://dx.doi.org/10.2478/s11756-018-0082-x
Ključne reči:
Pygidial gland secretions; Ground beetles; Antiproliferative effect; Cell lines; EllipticineIzvor:
Biologia, 2018Finansiranje / projekti:
- Ontogenetska karakterizacija filogenije bioraznovrsnosti (RS-MESTD-Basic Research (BR or ON)-173038)
- Karakterizacija i primena metabolita gljiva i utvrđivanje potencijala novih biofungicida (RS-MESTD-Basic Research (BR or ON)-173032)
- Foundation for Science and Technology (FCT, Portugal) (Grant No. SFRH/BPD/68344/2010)
URI
http://link.springer.com/10.2478/s11756-018-0082-xhttps://radar.ibiss.bg.ac.rs/handle/123456789/3092