Prognostic significance of myeloperoxidase in prediction in-hospital mortality in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention
2011
Authors:
Stanković, SAsanin, M
Vasiljević, Z
Majkić-Singh, N
Mihailović, Mirjana
Nikolajević, I
Ostojić, M
Document Type:
Conference object (Published version)
,
© 2011 by the European Society of Cardiology
Metadata
Show full item recordAbstract:
Background: The predictive value of myeloperoxidase (MPO) with respect to in-
hospital mortality in ST-segment elevation myocardial infarction (STEMI) treated
by primary percutaneous coronary intervention (PCI) is unknown. The aim of the
present study was to investigate MPO as a predictor of in-hospital mortality in
STEMI patients treated by primary PCI.
Methods: Study population consisted of 189 STEMI patients underwent primary
PCI. Plasma MPO level was measured 24h after symptom onset using chemilu-
minescent microparticle immunoassay (Abbott Diagnostics, Germany). The Re-
ceiver Operating Characteristic analysis was performed to identify the most useful
MPO cut-off level for the prediction of in-hospital mortality. The patients were di-
vided into two groups according to the cut-off MPO level.
Results: The incidence of in-hospital mortality was 5.8% (11/189 patients). It was
significantly higher in those with high MPO (≥840 pmol/L) (13.8%, 9/65 patients)
than in those with low MPO (<840 pmol/L) (1.6%, 2/124 patients) (p=0.001).
Patients with a high MPO had significantly more frequent anterior wall infarc-
tion (p<0.001), higher Killip class at admission (p=0.013), lower left ventricular
ejection fraction (LVEF) (p=0.011) and higher B-type natriuretic peptide (BNP)
(p=0.029) than patients with low MPO. Multiple logistic regression analysis re-
vealed that the independent predictors of in-hospital mortality were MPO (OR
3.88, 95%CI 1.13–13.34, p=0.031), BNP (OR 4.40, 95%CI 1.11–17.37, p=0.034),
lower LVEF (OR 0,88, 95%CI 0.80–0.97, p=0.009), estimated glomerular filtration
rate (OR 0,93, 95%CI 0.88–0.99, p=0.035), Killip class at admission (OR 10.76,
95%CI 1.23–94.01, p=0.032).
Conclusion: Plasma MPO level independently predicts in-hospital mortality in
STEMI patients treated by primary PCI.
In:
- ESC Congress 2011; 2011 Aug 37-31; Paris, France. 2011. p. 1064. (European Heart Journal; Vol. 32; Suppl. 1).
URI
http://eurheartj.oxfordjournals.org/content/32/suppl_1https://radar.ibiss.bg.ac.rs/handle/123456789/3206