Odnos između genetike i epigenetike - naučni izazovi u budućim fundamentalnim i translacionim istraživanjima
The relationship between genetics and epigenetics - the scientific challenges of future fundamental and translational research
2016
Тип документа:
Поглавље у монографији (Објављена верзија)
,
© Serbian Academy of Sciences and Arts
Метаподаци
Приказ свих података о документуАпстракт:
Epigenetics studies genetic factors and mechanisms that regulate the
expression of the genetic code without altering the DNA sequence. Epigenetic
processes regulate the expression of genes by chemical modifi cations of DNA
and chromatin structural proteins by DNA methylation and various forms of
post-translational modifi cations of histones, respectively, and through the
actions of small noncoding RNA molecules.
The main objective of epigenetic research groups is to defi ne the
mechanisms of epigenetics modifi cations that lie at the basis of an epigenetic
process. There are a several basic priorities for future research in epigenetics:
the establishment of links between genetic, epigenetic and environmental
factors over the life cycle and across generations, defi ning their roles in
health and disease, and determining the signifi cance for the development of
predisposition and progression of specifi c diseases.
A large number of scientifi c publications suggest that disturbances in
mechanisms which regulate epigenetic processes underlie several complex
pathologies, including diabetes mellitus as a complex metabolic disorder.
Although there are no completely effective preventive or therapeutic strategies
due to the complex multifactorial etiology and phenotype of different diseases,
the very plastic nature of the epigenome represents a potential target in the
design of future therapeutic strategies and novel epigenetic drugs.
Кључне речи:
Epigenetics; DNA methylation; Histone code; Diabetes; Genetics; Environmental factorsУ:
- Stevanović M, editor. Genes and genome. Belgrade: Serbian Academy of Sciences and Arts; 2016. p. 87–101.
URI
https://radar.ibiss.bg.ac.rs/handle/123456789/3272http://www.vbs.rs/scripts/cobiss?command=DISPLAY&base=99999&rid=1545699306&fmt=11&lani=sc