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Cytotoxic Activity of Royleanone Diterpenes from <i>Plectranthus madagascariensis</i> Benth
dc.creator | Matias, Diogo | |
dc.creator | Nicolai, Marisa | |
dc.creator | Saraiva, Lucília | |
dc.creator | Pinheiro, Rute | |
dc.creator | Faustino, Célia | |
dc.creator | Diaz Lanza, Ana | |
dc.creator | Pinto Reis, Catarina | |
dc.creator | Stanković, Tijana | |
dc.creator | Dinić, Jelena | |
dc.creator | Pešić, Milica | |
dc.creator | Rijo, Patrícia | |
dc.date.accessioned | 2019-05-16T12:26:37Z | |
dc.date.available | 2019-05-16T12:26:37Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | http://pubs.acs.org/doi/10.1021/acsomega.9b00512 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3349 | |
dc.description.abstract | Cytotoxicity screenings have identified Plectranthus plants as potential sources of antitumor lead compounds. In this work, several extracts from Plectranthus madagascariensis were prepared using different solvents (acetone, methanol, and supercritical CO2) and extraction techniques (maceration, ultrasound-assisted, and supercritical fluid extraction), and their chemical composition was detailed using high-performance liquid chromatography with a diode array detector. The cytotoxic activity of the major compounds identified, namely, rosmarinic acid (1) and abietane diterpenes 7α,6β-dihydroxyroyleanone (2), 7α-formyloxy-6β-hydroxyroyleanone (3), 7α-acetoxy-6β-hydroxyroyleanone (4), and coleon U (5), was evaluated in a battery of human cancer cell lines, including breast (MDA-MB-231, MCF-7), colon (HCT116), and lung (NCI-H460, NCI-H460/R) cancer, and also in healthy lung (MCR-5) cells. Royleanone (3) was isolated for the first time from P. madagascariensis, and its full spectroscopic characterization (proto... | en |
dc.relation | PADDIC 2013-2014 (ALIES-COFAC) | |
dc.relation | Fundaca̧ õ para a Cienciâ e Tecnologia | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | ACS Omega | |
dc.title | Cytotoxic Activity of Royleanone Diterpenes from <i>Plectranthus madagascariensis</i> Benth | en |
dc.type | article | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Диаз Ланза, Aна; Пинто Реис, Цатарина; Станковић, Тијана; Пешић, Милица; Ницолаи, Мариса; Динић, Јелена; Ријо, Патрíциа; Матиас, Диого; Сараива, Луцíлиа; Пинхеиро, Руте; Фаустино, Цéлиа; | |
dc.rights.holder | © 2019 American Chemical Society. | |
dc.citation.issue | 5 | |
dc.citation.volume | 4 | |
dc.identifier.doi | 10.1021/acsomega.9b00512 | |
dc.identifier.scopus | 2-s2.0-85065225229 | |
dc.identifier.wos | 000470094000024 | |
dc.citation.apa | Matias, D., Nicolai, M., Saraiva, L., Pinheiro, R., Faustino, C., Diaz Lanza, A., … Rijo, P. (2019). Cytotoxic Activity of Royleanone Diterpenes from Plectranthus madagascariensis Benth. ACS Omega, 4(5), 8094–8103. | |
dc.citation.vancouver | Matias D, Nicolai M, Saraiva L, Pinheiro R, Faustino C, Diaz Lanza A, Pinto Reis C, Stankovic T, Dinic J, Pesic M, Rijo P. Cytotoxic Activity of Royleanone Diterpenes from Plectranthus madagascariensis Benth. ACS Omega. 2019;4(5):8094–103. | |
dc.citation.spage | 8094 | |
dc.citation.epage | 8103 | |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs//bitstream/id/5007/ACSOmega_2019_4_5_8094-8103.pdf |