Role of astrocyte purinergic signaling in epilepsy.
2020
Document Type:
Article (Accepted Version)
,
© 2019 Wiley Periodicals, Inc.
Metadata
Show full item recordAbstract:
Epilepsy is characterized by unpredictable recurrent seizures resulting from hypersynchronous discharges from neuron assemblies. Increasing evidence indicates that aberrant astrocyte signaling to neurons plays an important role in driving the network hyperexcitability. Purinergic signaling is central in neuron-glia and glia-glia interactions and dysfunctions in communication pathways involving purinergic receptors have been reported in various CNS pathologies, such as Alzheimer disease, stroke, major depression, schizophrenia, and epilepsy. In the present review we will first discuss the mechanisms by which astrocytes influence neuronal activity. We will then review in more details recent evidence indicating that dysregulation of astrocyte purinergic signaling actively contributes to the appearance of abnormal neuronal activity in epilepsy.
Keywords:
Calcium signaling; Cytokine; Gliotransmission; Inflammation; MicrogliaSource:
Glia, 2020, 68, 9, 1677-1691Funding / projects:
- The effects of magnetic fields and other environmental stressors on the physiological responses and behavior of different species (RS-MESTD-Basic Research (BR or ON)-173027)
- EC‐H2020 MSCA‐ITN EU‐GliaPhD No. 722053
- Fédération pour la Recherche sur le Cerveau (FRC)
DOI: 10.1002/glia.23747
PubMed: 31705600
WoS: 000495216300001
Scopus: 2-s2.0-85074841159
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.23747https://radar.ibiss.bg.ac.rs/handle/123456789/3525