Effect of dental caries on periodontal inflammatory status: A split-mouth study.
2019
Autori:
Taso, ErvinStefanović, Vladimir
Gaudin, Alexis
Grujić, Jovan
Maldonado, Estela
Petković-Curcin, Aleksandra
Vojvodić, Danilo
Sculean, Anton
Rakić, Mia
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2019 Elsevier Ltd
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
OBJECTIVE This controlled split-mouth study aimed to estimate the effect of caries and related treatment on concentrations of interleukin (IL)-2, interferon (IFN)-γ, IL-12, IL-17A, IL-13, IL-10, IL-6, IL-5, IL-4, IL-22, tumor necrosis factor (TNF)-α, and IL1-β in gingival crevicular fluid (GCF) of caries affected teeth before (B), 7 (7D) and 30 (30D) days post-treatment and to compare them with concentrations from healthy teeth. DESIGN Study population included 81 systemically and periodontally healthy non-smokers exhibiting at least one shallow occlusal/ inter-proximal caries and one healthy tooth from the same morphologic group at the contralateral position. Following clinical exam, the GCF samples were collected baseline as well as 7D and 30D, while the biomarker measurement was performed using multiplex flowcytometry. RESULTS Caries affected teeth exhibited significantly higher levels of IFN-γ, IL-1β, IL-2, IL-4 and IL-6 when compared to healthy teeth. Post-treatment cytokines levels showed general trend of increase when compared to baseline, that was significant for IL-22 and IL-17 at 7D, while IFN-γ was significantly increased at 7D compared to the healthy teeth. At 30D, IFN-γ, TNF-α, IL-17 and IL-4 levels were significantly increased when compared to healthy teeth, while IL-2 levels were significantly higher than baseline levels. CONCLUSION Considering significantly increased periodontal levels of inflammatory markers in caries affected teeth and in response to performed treatment, it seems that dental caries and related restorative treatment might contribute to periodontal inflammation via additive effects already in early-stage caries.
Ključne reči:
Biomarker; Caries; Cytokine; Gingival crevicular fluid; Inflammation; PeriodontitisIzvor:
Archives of Oral Biology, 2019, 110, 104620-Finansiranje / projekti:
- Interakcija etiopatogenetskih mehanizama parodontopatije i paeriimplantitisa sa sistemskim bolestima današnjice (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41008)
- Plastičnost mozga tokom starenja: uticaj dijetalne restrikcije i anestezije (RS-MESTD-Basic Research (BR or ON)-173056)
DOI: 10.1016/j.archoralbio.2019.104620
PubMed: 31791000
WoS: 000523654000009
Scopus: 2-s2.0-85075627912
URI
https://www.sciencedirect.com/science/article/pii/S0003996919309392?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3550